東京大学

東京大学 東京大学 工学系研究科／医学系研究科 鄭雄一研究室

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大庭・鄭グループ

大庭・鄭グループトップページ

研究成果

2014－2015

大庭*: corresponding author

  1. Ohba S*, He X, Hojo H, McMahon AP: Distinct transcriptional programs underlie Sox9 regulation of the mammalian chondrocyte. Cell Rep 12(2):229-243, 2015
  2. Maeda Y, Yamamoto K, Yamakawa A, Aini H, Takato T, Chung UI, Ohba S*: The H2 blocker famotidine suppresses progression of ossification of the posterior longitudinal ligament in a mouse model. RMD Open 1:e000068, 2015
  3. Saito T, Ohba S, Yano F, Seto I, Yonehara Y, Takato T, Ogasawara T: Runx1 and Runx3 are downstream effectors of Nanog in promoting osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2. Cell Reprogram 17(3):227-234, 2015
  4. Hojo H, Ohba S, Chung UI: Signaling pathways regulating the specification and differentiation of the osteoblast lineage. Regenerative Therapy 1:57-62, 2015
  5. Sugita S, Hosaka Y, Okada K, Mori D, Yano F, Kobayashi H, Taniguchi Y, Mori Y, Okuma T, Chang S, Kawata M, Taketomi S, Chikuda H, Akiyama H, Kageyama R, Chung UI, Tanaka S, Kawaguchi H, Ohba S, Saito T: Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2. Proc Natl Acad Sci U S A 112(10):3080-3085, 2015
  6. Kitaura Y, Hojo H, Komiyama Y, Takato T, Chung UI, Ohba S*: Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice. PLoS ONE 9(10):e109597, 2014
  7. Kanke K, Masaki H, Saito T, Komiyama Y, Hojo H, Nakauchi H, Lichtler AC, Takato T, Chung UI, Ohba S*: Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free conditions. Stem Cell Reports 2(6):751-760, 2014
  8. Ohba S*, Chung UI: PTHrP action on skeletal development: a key for the controlled growth of endochondral bones. Clinc Rev Bone Miner Metab 12:130-141, 2014
  9. Honnami M, Choi S, Liu IL, Kamimura W, Taguchi T, Hojo H, Shimohata N, Ohba S, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M: Bone regeneration by the combined use of tetrapod-shaped calcium phosphate granules with basic fibroblast growth factor-binding ion complex gel in canine segmental radial defects. J Vet Med Sci 76(7):955-961, 2014
  10. Choi S, Liu I, Yamamoto K, Honnami M, Sakai T, Ohba S, Echigo R, Suzuki S, Chung UI, Sasaki N, Mochizuki M: Implantation of tetrapod-shaped granular artificial bones or β-tricalcium phosphate granules in a canine large bone-defect model. J Vet Med Sci 76(2):229-235, 2014
  11. Choi S, Honnami M, Liu I, Yamamoto K, Ohba S, Echigo R, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M: Cranioplasty with custom-made artificial bone after resection of multilobular bone tumor in a dog. J Vet Clin 31(1):46-50, 2014
  12. Yano F, Ohba S, Hosaka Y, Saito T, Chung UI: Disease-modifying effects of TD-198946 on progressed osteoarthritis in a mouse model. Ann Rheum Dis 73(11):2062-2064, 2014 (doi: 10.1136/annrheumdis-2014-205672
  13. Choi S, Liu IL, Yamamoto K, Honnami M, Ohba S, Echigo R, Sakai T, Igawa K, Nishimura R, Chung UI, Sasaki N, Mochizuki M: Comparison of the long-term effects on rabbit bone defects between Tetrabone® and β-tricalcium phosphate granules implantation. J Arif Organs 17(4):344-351, 2014
  14. Ha BG, Yonezawa T, Son MJ, Woo JT, Ohba S, Chung UI, Yagasaki K: Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. BioFactors 40(4):436-447, 2014

鄭

  1. Okada K, Fukai A, Mori D, Hosaka Y, Yano F, Chung U, Kawaguchi H, Tanaka S, Ikeda T, Saito T. Identification of SCAN domain zinc-finger gene ZNF449 as a novel factor of chondrogenesis. PLoS One 9:e115169, 2014.
  2. Kitaura Y, Hojo H, Komiyama Y, Takato T, Chung UI, Ohba S, Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice. PLoS ONE 9(10):e109597, 2014.
  3. Choi S, Liu IL, Yamamoto K, Honnami M, Ohba S, Echigo R, Sakai T, Igawa K, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M. Comparison of the long-term effects on rabbit bone defects between TetraboneR and β-tricalcium phosphate granules implantation. J Artif Organ 17:344-351, 2014.
  4. Li X, Kondo S, Chung U, Sakai T. Degradation Behavior of Polymer Gels Caused by Non-specific Cleavages of Network Strands. Chem Mater 26:5352-5357, 2014.
  5. Yano F, Ohba S, Hosaka Y, Saito T, Chung U. Disease-modifying effects of TD-198946 on progressed osteoarthritis in a mouse model. Ann Rheum Dis 73:2062-4, 2014.
  6. Mori Y, Chung U, Tanaka S, Saito T. Determination of differential gene expression profiles in superficial and deeper zones of mature rat articular cartilage using RNA sequencing of laser microdissected tissue specimens. Biomed Res 35(4):263-70, 2014.
  7. Mori Y, Mori D, Chung U, Tanaka S, Heierhorst J, Buchou T, Baudier J, Kawaguchi H, Saito T. S100A1 and S100B are dispensable for endochondral ossification during skeletal development. Biomed Res 35(4):243-50, 2014.
  8. Kanke K, Masaki H, Saito T, Komiyama Y, Hojo H, Nakauchi H, Lichtler AC, Takato T, Chung UI, Ohba S. Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free condition. Stem Cell Reports 2:751-760, 2014.
  9. Ha BG1, Yonezawa T, Son MJ, Woo JT, Ohba S, Chung UI, Yagasaki K. Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. BioFactors 40:436-47, 2014.
  10. Mori Y, Saito T, Chang SH, Kobayashi H, Ladel CH, Guehring H, Chung U, Kawaguchi H. Identification of fibroblast growth factor-18 as a molecule to protect adult articular cartilage by gene expression profiling. J Biol Chem 289(14):10192-200, 2014.
  11. Choi S, Honnami M, Liu I, Yamamoto K, Ohba S, Echigo R, Suzuki S, Nishimura R, Chung U, Sasaki N, Mochizuki M. Cranioplasty with Custom-made Artificial Bone after Resection of Multilobular Bone Tumor in a Dog. J Vet Clin 31:46-50, 2014.
  12. Kamata H,Akagi Y,Kayasuga-Kariya Y, Chung U, Sakai T. Non-swellable hydrogel without mechanical hysteresis. Science 343:873-875, 2014.
  13. Katashima T, Asai M, Urayama L, Chung U, Sakai T. Mechanical properties of Tetra-PEG gels with supercoiled network structure. J Chem Phys 140:074902, 2014.
  14. Elgali I, Igawa K, Palmquist A, Lenneras M, Xia W, Choi S, Chung U, Omar O, Thomsen P. Molecular and structural patterns of bone regeneration in surgically created defects containing bone substitutes. Biomaterials 35:3229-3242, 2014.
  15. Kondo S, Chung U, Sakai T. Effect of prepolymer architecture on the network structure formed by AB-type crosslink-coupling. Polymer J 46:14-20, 2014.
  16. Choi S, Liu I, Yamamoto K, Honnami M, Sakai T, Ohba S, Echigo R, Suzuki S, Nishimura R, Chung U, Sasaki N, Mochizuki M. Implantation of Tetrapod-shaped Granular Artificial Bones or β-Tricalcium Phosphate Granules in a Canine Large Bone-Defect Model. J Vet Med Sci 76:229-235, 2014.

2013

大庭*: corresponding author

  1. Zhang X, Peterson KA, Liu XS, McMahon AP, Ohba S (co-first): Gene regulatory networks mediating canonical Wnt signal directed control of pluripotency and differentiation in embyo stem cells. Stem Cells 31:2667-2679, 2013.
  2. Maeda Y, Hojo H, Shimohata N, Choi S, Yamamoto K, Takato T, Chung UI, Ohba S*: Bone healing by sterilizable calcium phosphate tetrapods eluting osteogenic molecules. Biomaterials 34(22):5530-5537, 2013.
  3. Komiyama Y, Ohba S*, Shimohata N, Nakajima K, Hojo H, Yano F, Takato T, Docheva D, Shukunami C, Hiraki Y, Chung UI: Tenomodulin expression in the periodontal ligament enhances cellular adhesion. PLoS ONE 8(4): e60203, 2013.
  4. Hojo H, Ohba S*, Taniguchi K, Shirai M, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Mishina Y, Yamada M, Konno T, Takato T, Kawaguchi H, Kambara H, Chung UI: Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium. J Biol Chem 288(14):9924-9932, 2013.
  5. Saito T, Saito T, Yano F, Mori D, Ohba S, Hojo H, Otsu M, Eto K, Nakauchi H, Tanaka S, Chung UI, Kawaguchi H: Generation of Col2a1-EGFP iPS cells for monitoring chondrogenic differentiation. PLoS ONE 8(9):e74137, 2013.
  6. Honnami M, Choi S, Liu I, Kamimura W, Taguchi T, Hojo H, Shimohata N, Ohba S, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M: Repair of rabbit segmental femoral defects by using a combination of tetrapod-shaped granular artificial bones and basic fibroblast growth factor-binding ion complex gel. Biomaterials 34(36):9056-9062, 2013.
  7. Yano F, Hojo H, Ohba S, Saito T, Honnami M, Mochizuki M, Takato T, Kawaguchi H, Chung UI: Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration. Biomaterials 34(22):5581-5587, 2013.
  8. Yano F, Hojo H, Ohba S, Fukai A, Hosaka Y, Ikeda T, Saito T, Hirata M, Chikuda H, Takato T, Kawaguchi H, Chung UI: A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis 72(5):748-753, 2013.
  9. Wu S, Kasim V, Kano MR, Tanaka, S, Ohba S, Miura Y, Miyata K, Liu X, Matsuhashi A, Chung UI, Yang L, Kataoka K, Nishiyama N, Miyagishi M: Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1&alpha in a p53-independent manner. Cancer Res 73(6):1787-1799, 2013.
  10. Ogasawara T, Ohba S, Yano F, Kawaguchi H, Chung UI, Saito T, Yonehara Y, Nakatsuka T, Mori Y, Takato T, Hoshi K: Nanog promotes osteogenic differentiation of the mouse mesenchymal cell line　C3H10T1/2 by modulating bone morphogenetic protein (BMP) signaling. J Cell Physiol 228(1):163-171, 2013.

鄭

  1. Li X, Khairulina K, Chung U, Sakai T. Migration behavior of rod-like dsDNA under electric field in homogeneous polymer networks.　Macromolecules 46:8665-8663, 2013.
  2. Takehara H, Nagaoka A, Noguchi J, Akagi T, Sakai T, Chung U, Kasai H, Ichiki T. Implementation of tetra-poly(ethylene glycol) hydrogel with high mechanical strength into microfluidic device technology. Biomicrofluidics 7:054109, 2013.
  3. Akagi Y, Sakurai H, Gong JP, Chung U, Sakai T. Fracture energy of polymer gels with controlled network structures. J Chem Phys 139:144905, 2013.
  4. Nakajima T, Fukuda Y, Kurokawa T, Sakai T, Chung U, Gong JP. Synthesis and Fracture Process Analysis of Double Network Hydrogels with a Well-Defined First Network. ACS Macro Letters 2:518-521, 2013.
  5. Kobayashi H, Hirata M, Saito T, Itoh S, Chung UI, Kawaguchi H.　Transcriptional induction of ADAMTS5 by an NF-κB family member RelA/p65 in chondrocytes during osteoarthritis development. J Biol Chem 288:28620-28629, 2013.
  6. Honnami M, Choi S,Liu I, Kamimura W, Taguchi T, Ichimura M, Urushizaki Y, Hojo H, Shimohata N, Ohba S, Amaya K, Koyama H, Nishimura R, Chung U, Sasaki N, Mochizuki M. Repair of rabbit segmental femoral defects by using a combination of tetrapod-shaped calcium phosphate granules and basic fibroblast growth factor-binding ion complex gel. Biomaterials 34:9056-9062, 2013.
  7. Saito T, Yano F, Mori D, Ohba S, Hojo H, Otsu M, Eto K, Nakauchi H, Tanaka S, Chung U, Kawaguchi H. Generation of Col2a1-EGFP iPS cells for monitoring chondrogenic　differentiation. PLoS ONE 8:e74137, 2013.
  8. Kayasuga-Kariya Y, Iwanaga S, Fujisawa A, Lin L, Suzuki S, Chung U, Shimohata N, Mochizuki M. Dermal cell damage induced by topical application of non-steroidal anti-inflammatory drugs is suppressed by trehalose co-lyophilization in ex vivo analysis. J Vet Med Sci 75:1619-1622,2013.
  9. Cabral H, Murakami M, Hojo H, Terada Y, Kano MR, Chung U, Nishiyama N, Kataoka K. Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis. Proc Natl Acad Sci USA 110:11397-11402, 2013
  10. Yano F, Hojo H, Ohba S, Saito T, Honnami M, Mochizuki M, Takato T, Kawaguchi H, Chung U. Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration. Biomaterials 34:5581-5587, 2013.
  11. Akagi Y, Gong JP, Chung U, Sakai T. Transition between Phantom and Affine Network Model Observed in Polymer Gels with Controlled Network Structure. Macromolecules 46:1035-1040, 2013.
  12. Maeda Y, Hojo H, Shimohata N, Choi S, Yamamoto K, Takato T, Chung U, Ohba S. Bone healing by sterilizable calcium phosphate tetrapods eluting osteogenic molecules. Biomaterials 34:5530-5537, 2013.
  13. Komiyama Y, Ohba S, Shimohata N, Nakajima K, Hojo H, Yano F, Takato T, Docheva D, Shukunami C, Hiraki Y, Chung U. Tenomodulin expression in the periodontal ligament enhances cellular adhesion. PLoS ONE 8:e60203, 2013.
  14. Hojo H, Ohba S, Taniguchi K, Shirai S, Yano F,Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N,Suzuki K, Mishina M, Yamada M, Konno T, Takato T,Kawaguchi H, Kambara H, Chung U. Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium. J Biol Chem 288:9924-9932, 2013.
  15. Kan A, Ikeda T, Fukai A, Nakagawa T, Nakamura K, Chung U, Kawaguchi H, Tabin CJ. SOX11 contributes to the regulation of GDF5 in joint maintenance. BMC Dev Biol 13:4, 2013.
  16. Wu S, Kasim V, Kano MR, Tanaka S, Ohba S, Miura Y, Miyata K, Liu X, Matsuhashi A, Chung U, Yang L, Kataoka K, Nishiyama N, Miyagishi M. Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner. Cancer Res 73:1787-1799, 2013.
  17. Choi S, Lee J, Igawa K, Liu I, Honnami M, Suzuki S, Nishimura R, Chung U, Sasaki N, Mochizuki M. Changes in bone regeneration by trehalose coating and basic fibroblast growth factor after implantation of tailor-made bone implants in dogs. J Vet Med Sci 75:721-726, 2013.
  18. Hosaka Y, Saito T, Sugita S, Hikata T, Kobayashi H, Fukai A, Taniguchi Y, Hirata M, Akiyama H, Chung U, Kawaguchi H. Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development. Proc Natl Acad Sci USA 110:1875-1880, 2013.
  19. Yano F, Saito T (contributed equally),Ogata N, Yamazawa T, Iino M, Chung U, Kawaguchi H. β-catenin regulates PTH/PTHrP receptor signals and chondrocyte hypertrophy through binding to its intracellular C-terminal region. Arthritis Rheum 65:429-35, 2013.
  20. Yamauchi H, Motomura N, Chung U, Sata M, Takai D, Saito A, Ono M, Takamoto S. Growth-associated hyperphosphatemia in young recipients accelerates aortic allograft calcification in a rat model. J Thorac Cardiovasc Surg 145:522-530, 2013.
  21. Ogasawara T, Ohba S, Yano F, Kawaguchi H, Chung U, Saito T, Yonehara Y, Nakatsuka T, Mori Y, Takato T, Hoshi K. Nanog promotes osteogenic differentiation of the mouse mesenchymal cell line　C3H10T1/2 by modulating bone morphogenetic protein (BMP) signaling. J Cell Physiol 228:163-171, 2013.
  22. Yano F, Ikeda T, Saito T, Ogata N, Chikuda H, Hojo H, Kimura A, Takeda S, Nakamura K, Takato T, Kawaguchi H, Chung U. A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis 72:748-53、2013.


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