鄭雄一研究室は、○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○サイト説明文が入ります。

研究成果

2017

大庭 (* corresponding author)

Zujur D, Kanke K, Lichtler AC, Hojo H, Chung UI, Ohba S*: Three-dimensional system enabling the maintenance and directed differentiation of pluripotent stem cells under defined conditions. Sci Adv 3(5):e1602875, 2017

Hayashi K, Okamoto F, Hoshi S, Katashima T, Zujur D, Li X, Shibayama M, Gilbert EP, Chung UI, Ohba S, Oshika T, Sakai T: Fast-forming hydrogel with ultraflow polymeric content as an artificial vitreous body. Nat Biomed Eng 1:44, 2017

Kawata M, Taniguchi Y, Mori D, Yano F, Ohba S, Chung UI, Grove E, Shimogori T, Mills AA, Tanaka S, Saito T: Different regulation of limb development by p63 transcript variants. PLoS ONE 12(3):e174122, 2017

Honnami M, Choi S, Liu IL, Kamimura W, Taguchi T, Ichimura M, Urushisaki Y, Shimohata N, Ohba S, Amaya K, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M: Repair of segmental radial defects in dogs by using tailor-made titanium mesh cages with plates combined with calcium phosphate granules and basic fibroblast growth factor-binding ion complex gel. J Artif Organs 20(1):91-98, 2017

Zujur D, Kanke K, Lichtler AC, Hojo H, Chung U, Ohba S: Three-dimensional system enabling the maintenance and directed differentiation of pluripotent stem cells under defined conditions. Sci Adv 3(5):e1602875, 2017

Hayashi K, Okamoto F, Hoshi S, Katashima T, Zujur D, Li X, Shibayama M, Gilbert EP, Chung U, Ohba S, Oshika T, Sakai T: Fast-forming hydrogel with ultraflow polymeric content as an artificial vitreous body. Nat Biomed Eng 1:44, 2017

Kawata M, Taniguchi Y, Mori D, Yano F, Ohba S, Chung U, Grove E, Shimogori T, Mills AA, Tanaka S, Saito T: Different regulation of limb development by p63 transcript variants. PLoS ONE 12(3):e174122, 2017

Honnami M, Choi S, Liu IL, Kamimura W, Taguchi T, Ichimura M, Urushisaki Y, Shimohata N, Ohba S, Amaya K, Koyama H, Nishimura R, Chung U, Sasaki N, Mochizuki M: Repair of segmental radial defects in dogs by using tailor-made titanium mesh cages with plates combined with calcium phosphate granules and basic fibroblast growth factor-binding ion complex gel. J Artif Organs 20(1):91-98, 2017

-2016

大庭 (* corresponding author)

原著論文

Hojo H, McMahon AP, Ohba S*: An emerging regulatory landscape for skeletal development. Trends Genet 32(12):774-787, 2016

Kashiwagi M, Hojo H, Kitaura Y, Maeda Y, Aini H, Takato T, Chung UI, Ohba S*: Local administration of a hedgehog agonist accelerates fracture healing in a mouse model. Biochem Biophys Res Commun 479(4):772-778, 2016

Ohba S*: Hedgehog signaling in endochondral ossification. J Dev Biol 4(2):20, 2016

He X, Ohba S (co-first), Hojo H, McMahon AP: AP-1 family members act with Sox9 to promote chondrocyte hypertrophy. Development 143(16):3012-3023, 2016

Hojo H, Ohba S, He X, Lai LP, McMahon AP: Sp7/Osterix is restricted to bone-forming vertebrates where it acts as a Dlx co-factor in osteoblast specification. Dev Cell 37(3):238-253, 2016

Aini H, Itaka K, Fujisawa A, Uchida H, Uchida S, Fukushima S, Kataoka K, Saito T, Chung UI, Ohba S*: Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment. Sci Rep 6:18743, 2016

Ohba S*, He X, Hojo H, McMahon AP: Distinct transcriptional programs underlie Sox9 regulation of the mammalian chondrocyte. Cell Rep 12(2):229-243, 2015

Maeda Y, Yamamoto K, Yamakawa A, Aini H, Takato T, Chung UI, Ohba S*: The H2 blocker famotidine suppresses progression of ossification of the posterior longitudinal ligament in a mouse model. RMD Open 1:e000068, 2015

Saito T, Ohba S, Yano F, Seto I, Yonehara Y, Takato T, Ogasawara T: Runx1 and Runx3 are downstream effectors of Nanog in promoting osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2. Cell Reprogram 17(3):227-234, 2015

Hojo H, Ohba S, Chung UI: Signaling pathways regulating the specification and differentiation of the osteoblast lineage. Regenerative Therapy 1:57-62, 2015

Sugita S, Hosaka Y, Okada K, Mori D, Yano F, Kobayashi H, Taniguchi Y, Mori Y, Okuma T, Chang S, Kawata M, Taketomi S, Chikuda H, Akiyama H, Kageyama R, Chung UI, Tanaka S, Kawaguchi H, Ohba S, Saito T: Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2. Proc Natl Acad Sci USA 112(10):3080-3085, 2015

Kitaura Y, Hojo H, Komiyama Y, Takato T, Chung UI, Ohba S*: Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice. PLoS ONE 9(10):e109597, 2014

Kanke K, Masaki H, Saito T, Komiyama Y, Hojo H, Nakauchi H, Lichtler AC, Takato T, Chung UI, Ohba S*: Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free conditions. Stem Cell Reports 2(6):751-760, 2014

Ohba S*, Chung UI: PTHrP action on skeletal development: a key for the controlled growth of endochondral bones. Clinc Rev Bone Miner Metab 12(3):130-141, 2014

Yano F, Ohba S, Hosaka Y, Saito T, Chung UI: Disease-modifying effects of TD-198946 on progressed osteoarthritis in a mouse model. Ann Rheum Dis 73(11):2062-2064, 2014

Honnami M, Choi S, Liu IL, Kamimura W, Taguchi T, Hojo H, Shimohata N, Ohba S, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M: Bone regeneration by the combined use of tetrapod-shaped calcium phosphate granules with basic fibroblast growth factor-binding ion complex gel in canine segmental radial defects. J Vet Med Sci 76(7):955-961, 2014

Choi S, Liu IL, Yamamoto K, Honnami M, Ohba S, Echigo R, Sakai T, Igawa K, Nishimura R, Chung UI, Sasaki N, Mochizuki M: Comparison of the long-term effects on rabbit bone defects between Tetrabone® and β-tricalcium phosphate granules implantation. J Arif Organs 17(4):344-351, 2014

Choi S, Liu I, Yamamoto K, Honnami M, Sakai T, Ohba S, Echigo R, Suzuki S, Chung UI, Sasaki N, Mochizuki M: Implantation of tetrapod-shaped granular artificial bones or β-tricalcium phosphate granules in a canine large bone-defect model. J Vet Med Sci 76(2):229-235, 2014

Choi S, Honnami M, Liu I, Yamamoto K, Ohba S, Echigo R, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M: Cranioplasty with custom-made artificial bone after resection of multilobular bone tumor in a dog. J Vet Clin 31(1):46-50, 2014

Ha BG, Yonezawa T, Son MJ, Woo JT, Ohba S, Chung UI, Yagasaki K: Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. BioFactors 40(4):436-447, 2014

Saito T, Yano F, Mori D, Ohba S, Hojo H, Otsu M, Eto K, Nakauchi H, Tanaka S, Chung UI, Kawaguchi H: Generation of Col2a1-EGFP iPS cells for monitoring chondrogenic differentiation. PLoS ONE 8(9):e74137, 2013

Honnami M, Choi S, Liu I, Kamimura W, Taguchi T, Hojo H, Shimohata N, Ohba S, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M: Repair of rabbit segmental femoral defects by using a combination of tetrapod-shaped granular artificial bones and basic fibroblast growth factor-binding ion complex gel. Biomaterials 34(36):9056-9062, 2013

Wu S, Kasim V, Kano MR, Tanaka, S, Ohba S, Miura Y, Miyata K, Liu X, Matsuhashi A, Chung UI, Yang L, Kataoka K, Nishiyama N, Miyagishi M: Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner. Cancer Res 73(6):1787-1799, 2013

Ogasawara T, Ohba S, Yano F, Kawaguchi H, Chung UI, Saito T, Yonehara Y, Nakatsuka T, Mori Y, Takato T, Hoshi K: Nanog promotes osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2 by modulating bone morphogenetic protein (BMP) signaling. J Cell Physiol 228(1):163-171, 2013

Yano F, Hojo H, Ohba S, Fukai A, Hosaka Y, Ikeda T, Saito T, Hirata M, Chikuda H, Takato T, Kawaguchi H, Chung UI: A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis 72(5):748-753, 2013

Yano F, Hojo H, Ohba S, Saito T, Honnami M, Mochizuki M, Takato T, Kawaguchi H, Chung UI: Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration. Biomaterials 34(22):5581-5587, 2013

Zhang X, Peterson KA, Liu XS, McMahon AP, Ohba S (co-first): Gene regulatory networks mediating canonical Wnt signal directed control of pluripotency and differentiation in embyo stem cells. Stem Cells 31(12):2667-2679, 2013

Maeda Y, Hojo H, Shimohata N, Choi S, Yamamoto K, Takato T, Chung UI, Ohba S*: Bone healing by sterilizable calcium phosphate tetrapods eluting osteogenic molecules. Biomaterials 34(22):5530-5537, 2013

Komiyama Y, Ohba S*, Shimohata N, Nakajima K, Hojo H, Yano F, Takato T, Docheva D, Shukunami C, Hiraki Y, Chung UI: Tenomodulin expression in the periodontal ligament enhances cellular adhesion. PLoS ONE 8(4): e60203, 2013

Hojo H, Ohba S*, Taniguchi K, Shirai M, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Mishina Y, Yamada M, Konno T, Takato T, Kawaguchi H, Kambara H, Chung UI: Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium. J Biol Chem 288(14):9924-9932, 2013

Hojo H, Ohba S*, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Takato T, Kawaguchi H, Chung UI: Gli1 protein participates in the hedgehog-mediated specification of the osteoblast lineage during endochondral ossification. J Biol Chem 287(21):17860-17869, 2012

Yamamoto K, Hojo H, Koshima I, Chung UI, Ohba S*: Famotidine suppresses osteogenic differentiation of tendon cells in vitro and pathological calcification of tendon in vivo. J Orthop Res 30(12):1958-1962, 2012 (doi: 10.1002/jor.22146)

Ohba S*, Hojo H, Chung UI: Bioactive factors for tissue regeneration: State of Art. Muscles Ligaments Tendons J 2(3):193-203, 2012

Ohba S, Hojo H, Chung UI: Current progress on tissue engineering of bone and cartilage. Endocrinol Metab 27(1):1-11, 2012

Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Kan A, Ikeda T, Yonezawa T, Woo JT, Takato T, Nakamura K, Kawaguchi H, Chung UI: Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system. J Bone Miner Metab 28(6):627-633, 2010

Hojo H, Ohba S, Yano F, Chung UI: Coordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development. J Bone Miner Metab 28(5):489-502, 2010

Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, Kawaguchi H: Transcriptional regulation of endochondral ossification by HIF2A during skeletal growth and osteoarthritis development. Nat Med 16(6):678-686, 2010

Nakajima K, Komiyama Y, Hojo H, Ohba S, Yano F, Nishikawa N, Ihara S, Aburatani H, Takato T, Chung UI: Enhancement of bone formation ex vivo and in vivo by a helioxanthin-derivative. Biochem Biophys Res Commun 395(4):502-508, 2010

Zhao J, Ohba S, Komiyama Y, Shinkai M, Chung UI, Nagamune T: Icariin: A Potential Osteoinductive Compound for Bone Tissue Engineering. Tissue Eng Part A 16(1):233-243, 2010

Ohba S, Yano F, Chung UI: Tissue engineering of bone and cartilage. IBMS BoneKEy 6(11):405-419, 2009

Ogasawara T, Ohba S, Fujihara Y, Takahashi T, Liu G, Chikazu D, Suenaga H, Chung UI, Yoda T, Mori Y, Susami T, Takato T, Hoshi K: Transforming growth factor-b1 in combination with fibroblast growth factor-2 and insulin-like growth factor-I for chondrocyte proliferation culture and cartilage regenerative medicine. Asian J Oral Maxillofac Surg 21(1-2):18-26, 2009

Wang W, Itaka K, Ohba S, Nishiyama N, Chung UI, Yamasaki Y, Kataoka K: 3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells. Biomaterials 30(14):2705-2715, 2009

Zhao J, Shinkai M, Takezawa T, Ohba S, Chung UI, Nagamune T: Bone regeneration using collagen type I vitrigel with bone morphogenetic protein-2. J Biosci Bioeng 107(3):318-323, 2009

Hirata M, Kugimiya F, Fukai A, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Saito T, Yano F, Ikeda T, Nakamura K, Chung UI, Kawaguchi H: C/EBPβ promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57Kip2. PLoS ONE 4(2):e4543, 2009

Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Nakamura K, Chung UI, Kawaguchi H: Identification of the core element responsive to Runx2 in the promoter of human type X collagen gene. Arthritis Rheum 60(1):166-178, 2008

Hojo H, Igawa K, Ohba S, Yano F, Nakajima K, Komiyama Y, Ikeda T, Lichtler AC, Woo JT, Yonezawa T, Takato T, Chung UI: Development of high-throughput screening system for osteogenic drugs using a cell-based sensor. Biochem Biophys Res Commun 376(2):375-379, 2008

Ohba S*, Kawaguchi H, Kugimiya F, Ogasawara T, Kawamura N, Saito T, Ikeda T, Fujii K, Miyajima T, Kuramochi A, Miyashita T, Oda H, Nakamura K, Takato T, Chung UI: Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity. Dev Cell 14(5):689-699, 2008

Tamiya H, Ikeda T, Jung JH, Saito T, Jung YK, Ohba S, Kawaguchi H, Chung UI, Choi JY: Analysis of the Runx2 promoter in osseous and non-osseous cells and identification of HIF2A as a potent transcriptional activator. Gene 416(1-2):53-60, 2008

Zhao J, Ohba S, Shinkai M, Chung UI, Nagamune T: Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner. Biochem Biophys Res Commun 369(2):444-448, 2008

Kawamura N, Kugimiya F, Oshima Y, Ohba S, Ikeda T, Saito T, Shinoda Y, Kawasaki Y, Ogata N, Hoshi K, Akiyama T, Tobe T, Kadowaki T, Azuma Y, Tanaka S, Nakamura K, Chung UI, Kawaguchi H: Akt1 in osteoblasts and osteoclasts controls bone remodeling. PLoS ONE 2(10):e1058, 2007

Kugimiya F, Kawaguchi H, Ohba S, Kawamura N, Hirata M, Chikuda H, Azuma Y, Woodgett J, Nakamura K, Chung UI: GSK-3β controls osteogenesis through regulating Runx2 activity. PLoS ONE 2(9):e837, 2007

Itaka K, Ohba S (co-first), Miyata K, Kawaguchi H, Nakamura K, Takato T, Chung UI, Kataoka K: Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles. Mol Ther 15(9):1655-1662, 2007

Ohba S, Ikeda T, Kugimiya F, Yano F, Lichtler AC, Nakamura K, Takato T, Kawaguchi H, Chung UI: Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell-based sensor. FASEB J 21(8):1777-1787, 2007

Ohba S, Nakajima K, Komiyama Y, Kugimiya F, Igawa K, Itaka K, Moro T, Nakamura K, Kawaguchi H, Takato T, Chung UI: A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner. Biochem Biophys Res Commun 357(4):854-860, 2007

Kugimiya F, Ohba S, Nakamura K, Kawaguchi H, Chung UI: Physiological role of bone morphogenetic proteins in osteogenesis. J Bone Miner Metab 24(2):95-99, 2006

Kugimiya F, Yano F, Ohba S, Igawa K, Nakamura K, Kawaguchi H, Chung UI: Mechanism of osteogenic induction by FK506 via BMP/Smad pathways. Biochem Biophys Res Commun 338(2):872-879, 2005

Kugimiya F, Kawaguchi H, Kamekura S, Chikuda H, Ohba S, Yano F, Ogata N, Katagiri T, Harada Y, Azuma Y, Nakamura K, Chung UI: Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation. J Biol Chem 280(42):35704-35712, 2005

Kawaguchi H, Akune T, Yamaguchi M, Ohba S, Ogata N, Chung UI, Kubota N, Terauchi Y, Kadowaki T, Nakamura K: Distinct effects of PPARgamma insufficiency on bone marrow cells, osteoblasts, and osteoclastic cells. J Bone Miner Metab 23(4):275-279, 2005

Yano F, Kugimiya F, Ohba S, Ikeda T, Chikuda H, Ogasawara T, Ogata N, Takato T, Nakamura K, Kawaguchi H, Chung UI: The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner. Biochem Biophys Res Commun 333(4):1300-1308, 2005

Chikazu D, Ohba S, Ogasawara T, Saijyo H, Mori Y, Tomizuka K, Kawaguchi H, Yonehara Y, Susami T, Takato T: Combination of platelet-rich plasma and cyclooxygenase-2 inhibitor potently stimulates bone marrow stromal cell proliferation in vitro. Asian J Oral Maxillofac Surg 17(2):81-87, 2005

Akune T, Ohba S, Kamekura S, Yamaguchi M, Chung UI, Kubota N, Terauchi Y, Harada Y, Azuma Y, Nakamura K, Kadowaki T, Kawaguchi H: PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 113(6):846-855, 2004

Long F, Chung UI, Ohba S, McMahon J, Kronenberg HM, McMahon AP: Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131(6):1309-1318, 2004

Kumamoto H, Ohba S, Suzuki T, Ooya K: Immunohistochemical expression of integrins and CD44 in ameloblastoma. Oral Med Pathol 6(2):73-78, 2001

著書

大庭伸介:コラム-変形性関節症の遺伝子治療, 最新医学別冊 診断と治療のABC「変形性関節症」, 147-148, 最新医学社, 東京, 2017

大庭伸介:15章3節 骨形成と転写制御, 遺伝子発現制御機構 クロマチン・転写制御・エピジェネティクス(田村隆明, 浦聖恵編), 164-166, 東京化学同人, 東京, 2017

大庭伸介, 鄭雄一:第11章Hedgehogシグナル, サイトカイン・増殖因子キーワード事典(宮園浩平, 秋山徹, 宮島篤, 宮沢恵二編)375-383, 羊土社, 東京, 2015

大庭伸介, 鄭雄一:多能性幹細胞を使った骨再生, 再生医療叢書(日本再生医療学会監修)-6 骨格系(脇谷滋之, 鄭雄一編), 128-140, 朝倉書店, 東京, 2012

大庭伸介:骨形成シグナルの解明と骨再生医学への応用, 医薬理工の異分野融合研究から見えたナノバイオの未来(東京大学ナノバイオインテグレーション研究拠点編), 60, エクスナレッジ, 東京, 2010

大庭伸介, 鄭雄一:骨代謝を制御する因子, 最新整形外科学体系(越智隆弘編)1 運動器の生物学と生体力学, 19-24, 中山書店, 東京, 2008

大庭伸介, 鄭雄一:組織再生誘導と分子シグナルの最適化, ティッシュエンジニアリング2007(田畑泰彦, 岡野光夫監修), 96-99, 日本医学館, 東京, 2007

大庭伸介, 井川和代, 中村耕三, 川口浩, 高戸毅, 鄭雄一:骨・軟骨の再生医療, 老年医学update 2005-06(日本老年医学会雑誌編集委員会編), 199-206, メジカルビュー社, 東京, 2005

和文総説

大庭伸介:骨軟骨発生の制御メカニズムを基盤にした組織再生療法, Clin Calcium 26(12):1765-1771, 2016

菅家康介, 鄭雄一, 大庭伸介:人工骨による骨再生, 腎と骨代謝 28(4):285-292, 2015

菅家康介, 鄭雄一, 大庭伸介:ヘッジホッグシグナルによる軟骨内骨化の制御, THE BONE 27(4):27-33, 2013

菅家康介, 大庭伸介, 鄭雄一:骨・軟骨形成の分子基盤と再生医療, 細胞 45(1):5-8, 2013

北條宏徳, 大庭伸介, 鄭雄一:目で見るBone Biology「ヘッジホッグ(Hh)シグナル」, 骨粗鬆症治療 12(3):1-4, 2013

大庭伸介, 鄭雄一:骨形成シグナルの解明と人工骨の開発, Clin Calcium 23(12):31-37, 2013

大庭伸介, 鄭雄一:再生医療とDDS, Drug delivery system 26(1), 46-51, 2011

北條宏徳, 大庭伸介, 鄭雄一:軟骨内骨化におけるヘッジホッグシグナルの役割, 細胞工学 30(3), 238-242, 2011

北條宏徳, 大庭伸介, 鄭雄一:肥大軟骨細胞は軟骨内骨化における軟骨形成と骨形成を制御する, 口腔組織培養学会誌 19(2):1-11, 2010

小笠原徹, 大庭伸介:細胞周期制御を利用した骨粗鬆症治療法開発のための基礎的研究, Osteoporosis Japan 18(4):61-63, 2010

大庭伸介, 鄭雄一:骨軟骨領域における再生医学の現状と展望, BIO Clinica 25(1):32-35, 2010

緒方直史, 大庭伸介, 鄭雄一, 川口浩:骨代謝と骨形成~骨形成への最適化シグナル~, Clin Calcium 18(12):1707-1712, 2008

大庭伸介, 鄭雄一:Cbfbの制御を介したBMPシグナルとRunx2による骨芽細胞分化, 新時代の骨粗鬆症学 増刊号:71-74, 2007

大庭伸介, 井川和代, 中村耕三, 川口浩, 高戸毅, 鄭雄一:骨・軟骨の再生医療, 日本老年医学会雑誌 41(6):582-588, 2004

大庭伸介, 鄭雄一:ヘッジホッグと軟骨細胞, 腎と骨代謝16(3):229-236, 2003

大庭伸介, 鄭雄一:PTHrPの作用, 腎と骨代謝 16(2):131-141, 2003

原著論文


Kashiwagi M, Hojo H, Kitaura Y, Maeda Y, Aini H, Takato T, Chung U, Ohba S: Local administration of a hedgehog agonist accelerates fracture healing in a mouse model. Biochem Biophys Res Commun 479(4):772-778, 2016

Aini H, Itaka K, Fujisawa A, Uchida H, Uchida S, Fukushima S, Kataoka K, Saito T, Chung U, Ohba S: Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment. Sci Rep 6:18743, 2016

Katashima T, Chung U, Sakai T. Effect of Swelling and Deswelling on Mechanical Properties of Polymer Gels. Macromolecular Symposia 358: 128-139, 2015

Chang SH, Yasui T, Taketomi S, Matsumoto T, Kim-Kaneyama JR, Omiya T, Hosaka Y, Inui H, Omata Y, Yamagami R, Mori D, Yano F, Chung U, Tanaka S, Saito T. Comparison of mouse ankles and establishment of mouse ankle osteoarthritis models by surgically-induced instability. Osteoarthritis Cartilage 24:688-697, 2015

Kondo S, Hiroi T, Han Y, Kim M, Shibayama M, Chung U, Sakai T. Reliable hydrogel with mechanical 'fuse link' in an aqueous environment. Adv Mater 27:7407-7411, 2015

Kamata H, Li X, Chung U, Sakai T. Design of Hydrogels for Biomedical Applications. Adv Healthcare Mater 4:2360-2374, 2015

Katashima T, Urayama K, Chung U, Sakai T. Probing the cross-effect of strains in non-linear elasticity of nearly regular polymer networks by pure shear deformation. J Chem Phys 142:174908, 2015

Khairulina K, Li X, Nishi K, Shibayama M, Chung U, Sakai T. Electrophoretic mobility of semi-flexible double-stranded DNA in defect-controlled polymer networks: Mechanism investigation and role of structural parameters. J Chem Phys 142:234904, 2015

Maeda Y, Yamamoto K, Yamakawa A, Aini H, Takato T, Chung U, Ohba S. The H2 blocker famotidine suppresses progression of ossification of the posterior longitudinal ligament in a mouse model. RMD Open 1:e000068, 2015

Saito T, Yano F, Mori D, Kawata M, Hoshi K, Takato T, Masaki H, Otsu M, Eto K, Nakauchi H, Chung U, Tanaka S. Hyaline Cartilage Formation and Tumorigenesis of Implanted Tissues Derived from Human Induced Pluripotent Stem Cells. Biomed Res 36:179-186, 2015

Haishima Y, Kawakami T, Fukui C, Tanoue A, Yuba T, Ozono S, Kumada H, Inoue K, Morikawa T, Takahashi M, Fujisawa A, Yamasaki K, Nomura Y, Isama K, Chung U, Ogawa K, Niimi S, Yoshida M. Characterization of alternative plasticizers in polyvinyl chloride sheets for blood containiers. J Vinyl Add Technol doi:10.1002/vnl.21472, 2015

Sugita S, Hosaka Y, Okada K, Mori D, Yano F, Kobayashi H, Taniguchi Y, Mori Y, Okuma T, Chang SH, Kawata M, Taketomi S, Chikuda H, Akiyama H, Kageyama R, Chung U, Tanaka S, Kawaguchi H, Ohba S, Saito T. Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2. Proc Natl Acad Sci USA 112:3080-3085, 2015

Uryu T, Matsumoto N, Namaki S, Mashimo T, Tamagawa T, Yasumitsu T, Okudera M, Komiyama K, Chung U, Honda K, Arai Y, Yonehara Y. Histochemical and Radiological Study of Bone Regeneration by the Combinatorial Use of Tetrapod-Shaped Artificial Bone and Collagen. J Hard Tissue Biol 24:199-210, 2015

Iwata J, Namaki S, Mashimo T, Honda K, Chung U, Yonehara Y. Augmentation of flat bone area using tetrapod-shaped artificial bone in rats. J Hard Tissue Biol 24:69-76, 2015

Okuma T, Hirata M, Yano F, Mori D, Kawaguchi H, Chung U, Tanaka S, Saito T. Regulation of mouse chondrocyte differentiation by CAAT/enhancer-binding proteins. Biomed Res 36:21-29, 2015

Hojo H, Ohba S, Chung U. Signaling pathways regulating the specification and differentiation of the osteoblast lineage. Regenerative Therapy 1:57-62, 2015

Okada K, Fukai A, Mori D, Hosaka Y, Yano F, Chung U, Kawaguchi H, Tanaka S, Ikeda T, Saito T. Identification of SCAN domain zinc-finger gene ZNF449 as a novel factor of chondrogenesis. PLoS One 9:e115169, 2014

Kitaura Y, Hojo H, Komiyama Y, Takato T, Chung U, Ohba S. Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice. PLoS ONE 9(10):e109597, 2014

Choi S, Liu IL, Yamamoto K, Honnami M, Ohba S, Echigo R, Sakai T, Igawa K, Suzuki S, Nishimura R, Chung U, Sasaki N, Mochizuki M. Comparison of the long-term effects on rabbit bone defects between Tetrabone® and β-tricalcium phosphate granules implantation. J Artif Organ 17:344-351, 2014

Li X, Kondo S, Chung U, Sakai T. Degradation Behavior of Polymer Gels Caused by Non-specific Cleavages of Network Strands. Chem Mater 26:5352-5357, 2014

Yano F, Ohba S, Hosaka Y, Saito T, Chung U. Disease-modifying effects of TD-198946 on progressed osteoarthritis in a mouse model. Ann Rheum Dis 73:2062-4, 2014

Mori Y, Chung U, Tanaka S, Saito T. Determination of differential gene expression profiles in superficial and deeper zones of mature rat articular cartilage using RNA sequencing of laser microdissected tissue specimens. Biomed Res 35(4):263-70 2014

Mori Y, Mori D, Chung U, Tanaka S, Heierhorst J, Buchou T, Baudier J, Kawaguchi H, Saito T. S100A1 and S100B are dispensable for endochondral ossification during skeletal development. Biomed Res 35(4):243-50, 2014

Kanke K, Masaki H, Saito T, Komiyama Y, Hojo H, Nakauchi H, Lichtler AC, Takato T, Chung U, Ohba S. Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free condition. Stem Cell Reports 2:751-760, 2014

Ha BG, Yonezawa T, Son MJ, Woo JT, Ohba S, Chung U, Yagasaki K. Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. BioFactors 40:436-47, 2014

Mori Y, Saito T, Chang SH, Kobayashi H, Ladel CH, Guehring H, Chung U, Kawaguchi H. Identification of fibroblast growth factor-18 as a molecule to protect adult articular cartilage by gene expression profiling. J Biol Chem 289(14):10192-200, 2014

Ohba S, Chung U. PTHrP action on skeletal development: a key for the controlled growth of endochondral bones. Clin Rev Bone Miner Metab 12: 130-141, 2014

Choi S, Honnami M, Liu I, Yamamoto K, Ohba S, Echigo R, Suzuki S, Nishimura R, Chung U, Sasaki N, Mochizuki M. Cranioplasty with Custom-made Artificial Bone after Resection of Multilobular Bone Tumor in a Dog. J Vet Clin 31:46-50,2014

Kamata H,Akagi Y,Kayasuga-Kariya Y, Chung U, Sakai T. Non-swellable hydrogel without mechanical hysteresis. Science 343:873-875, 2014

Katashima T, Asai M, Urayama L, Chung U, Sakai T. Mechanical properties of Tetra-PEG gels with supercoiled network structure. J Chem Phys 140:074902, 2014

Elgali I, Igawa K, Palmquist A, Lennerås M, Xia W, Choi S, Chung U, Omar O, Thomsen P. Molecular and structural patterns of bone regeneration in surgically created defects containing bone substitutes. Biomaterials 35:3229-3242, 2014

Kondo S, Chung U, Sakai T. Effect of prepolymer architecture on the network structure formed by AB-type crosslink-coupling. Polymer J 46:14-20, 2014

Choi S, Liu I, Yamamoto K, Honnami M, Sakai T, Ohba S, Echigo R, Suzuki S, Nishimura R, Chung U, Sasaki N, Mochizuki M. Implantation of Tetrapod-shaped Granular Artificial Bones or β-Tricalcium Phosphate Granules in a Canine Large Bone-Defect Model. J Vet Med Sci 76:229-235, 2014

Li X, Khairulina K, Chung U, Sakai T. Migration behavior of rod-like dsDNA under electric field in homogeneous polymer networks. Macromolecules 46:8665-8663, 2013

Takehara H, Nagaoka A, Noguchi J, Akagi T, Sakai T, Chung U, Kasai H, Ichiki T. Implementation of tetra-poly(ethylene glycol) hydrogel with high mechanical strength into microfluidic device technology. Biomicrofluidics 7:054109, 2013

Akagi Y, Sakurai H, Gong JP, Chung U, and Sakai T. Fracture energy of polymer gels with controlled network structures. J Chem Phys 139:144905, 2013

Nakajima T, Fukuda Y, Kurokawa T, Sakai T, Chung U, Gong JP. Synthesis and Fracture Process Analysis of Double Network Hydrogels with a Well-Defined First Network. ACS Macro Letters 2:518-521, 2013

Kobayashi H, Hirata M, Saito T, Itoh S, Chung U, Kawaguchi H. Transcriptional induction of ADAMTS5 by an NF-κB family member RelA/p65 in chondrocytes during osteoarthritis development. J Biol Chem 288:28620-28629, 2013

Honnami M, Choi S,Liu I, Kamimura W, Taguchi T, Ichimura M, Urushizaki Y, Hojo H, Shimohata N, Ohba S, Amaya K, Koyama H, Nishimura R, Chung U, Sasaki N, Mochizuki M. Repair of rabbit segmental femoral defects by using a combination of tetrapod-shaped calcium phosphate granules and basic fibroblast growth factor-binding ion complex gel. Biomaterials 34:9056-9062, 2013

Saito T, Yano F, Mori D, Ohba S, Hojo H, Otsu M, Eto K, Nakauchi H, Tanaka S, Chung U, Kawaguchi H. Generation of Col2a1-EGFP iPS cells for monitoring chondrogenic differentiation. PLoS ONE 8:e74137, 2013

Kayasuga-Kariya Y, Iwanaga S, Fujisawa A, Lin L, Suzuki S, Chung U, Shimohata N, Mochizuki M. Dermal cell damage induced by topical application of non-steroidal anti-inflammatory drugs is suppressed by trehalose co-lyophilization in ex vivo analysis. J Vet Med Sci 75:1619-1622, 2013

Cabral H, Murakami M, Hojo H, Terada Y, Kano MR, Chung U, Nishiyama N, Kataoka K. Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis. Proc Natl Acad Sci USA 110:11397-11402, 2013

Yano F, Hojo H, Ohba S, Saito T, Honnami M, Mochizuki M, Takato T, Kawaguchi H, Chung U. Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration. Biomaterials 34:5581-5587, 2013

Akagi Y, Gong JP, Chung U, Sakai T. Transition between Phantom and Affine Network Model Observed in Polymer Gels with Controlled Network Structure. Macromolecules 46:1035-1040, 2013

Maeda Y, Hojo H, Shimohata N, Choi S, Yamamoto K, Takato T, Chung U, Ohba S. Bone healing by sterilizable calcium phosphate tetrapods eluting osteogenic molecules. Biomaterials 34:5530-5537, 2013

Komiyama Y, Ohba S, Shimohata N, Nakajima K, Hojo H, Yano F, Takato T, Docheva D, Shukunami C, Hiraki Y, Chung U. Tenomodulin expression in the periodontal ligament enhances cellular adhesion. PLoS ONE 8:e60203, 2013

Hojo H, Ohba S, Taniguchi K, Shirai S, Yano F,Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N,Suzuki K, Mishina M, Yamada M, Konno T, Takato T,Kawaguchi H, Kambara H, Chung U. Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium. J Biol Chem 288:9924-9932, 2013

Kan A, Ikeda T, Fukai A, Nakagawa T, Nakamura K, Chung U, Kawaguchi H, Tabin CJ. SOX11 contributes to the regulation of GDF5 in joint maintenance. BMC Dev Biol 13:4, 2013

Wu S, Kasim V, Kano MR, Tanaka S, Ohba S, Miura Y, Miyata K, Liu X, Matsuhashi A, Chung U, Yang L, Kataoka K, Nishiyama N, Miyagishi M. Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner. Cancer Res 73:1787-1799, 2013

Choi S, Lee J, Igawa K, Liu I, Honnami M, Suzuki S, Nishimura R, Chung U, Sasaki N, Mochizuki M. Changes in bone regeneration by trehalose coating and basic fibroblast growth factor after implantation of tailor-made bone implants in dogs. J Vet Med Sci 75:721-726, 2013

Hosaka Y, Saito T, Sugita S, Hikata T, Kobayashi H, Fukai A, Taniguchi Y, Hirata M, Akiyama H, Chung U, Kawaguchi H. Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development. Proc Natl Acad Sci USA 110:1875-1880, 2013

Yano F, Saito T (contributed equally),Ogata N, Yamazawa T, Iino M, Chung U, Kawaguchi H. β-catenin regulates PTH/PTHrP receptor signals and chondrocyte hypertrophy through binding to its intracellular C-terminal region. Arthritis Rheum 65:429-35, 2013

Yamauchi H, Motomura N, Chung U, Sata M, Takai D, Saito A, Ono M, Takamoto S. Growth-associated hyperphosphatemia in young recipients accelerates aortic allograft calcification in a rat model. J Thorac Cardiovasc Surg 145:522-530, 2013

Ogasawara T, Ohba S, Yano F, Kawaguchi H, Chung U, Saito T, Yonehara Y, Nakatsuka T, Mori Y, Takato T, Hoshi K. Nanog promotes osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2 by modulating bone morphogenetic protein (BMP) signaling. J Cell Physiol 228:163-171, 2013

Yano F, Ikeda T, Saito T, Ogata N, Chikuda H, Hojo H, Kimura A, Takeda S, Nakamura K, Takato T, Kawaguchi H, Chung U. A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis 72:748-53, 2013

Ohba S, Hojo H, Chung U. Bioactive factors for tissue regeneration: state of the art. Muscles Ligaments Tendons J 16:193-203, 2012

Nishi K, Chijiishi M, Katsumoto Y, Nakao T, Fujii K, Chung U, Noguchi H, Sakai T, Shibayama M. Rubber Elasticity for Incomplete Polymer Networks. J Chem Phys 137:224903, 2012

Itoh S, Saito T, Hirata M, Ushita M, Ikeda T, Woodgett JR, Algl H, Schmid RM, Chung U, and Kawaguchi H. GSK-3α and GSK-3β are involved in early stages of chondrocyte differentiation with functional redundancy through RelA phosphorylation. J Biol Chem 287:29227-36, 2012

Lin L, Kayasuga Y, Shimohata N, Kamata H, Suzuki S, Echigo R, Mochizuki M, Chung U, Sasaki N. Lyophilized Aspirin with Trehalose May Decrease the Incidence of Gastric Injuries in Healthy Dogs. J Vet Med Sci 74:1511-6, 2012

Kamata H, Chung U, Shibayama M, Sakai T. Anomalous volume phase transition in a polymer gel with alternative hydrophilic/amphiphilic sequence. Soft Matter 8:6876-6879, 2012

Katashima T, Urayama K, Chung U, Sakai T. Strain energy density function of near-ideal polymer network estimated by biaxial deformation of Tetra-PEG gel. Soft Matter 8:8217-8222, 2012

Yamamoto K, Hojo H, Koshima I, Chung U, Ohba S. Famotidine suppresses osteogenic differentiation of tendon cells in vitro and pathological calcification of tendon in vivo. J Orthop Res 30:1958-1962, 2012

Echigo R, Shimohata N, Karatsu K, Yano F, Kayasuga-Kariya Y, Fujisawa A, Ohto T, Kita Y, Nakamura M, Suzuki S, Mochizuki M, Shimizu T, Chung U, Sasaki N. Trehalose treatment suppresses inflammation, oxidative stress, and vasospasm induced by experimental subarachnoid hemorrhage. J Tra Med 10:80, 2012

Hojo H, Ohba S, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Suzuki K, Takato T, Kawaguchi H, Chung U. Gli1 participates in the hedgehog-mediated specification of the osteoblast lineage during endochondral ossification. J Biol Chem 287:17860-17869, 2012

Asai H, Fujii K, Ueki T, Sakai T, Chung U, Watanabe M, Han Y, Kim T, Shibayama M. Structural Analysis of High Performance Ion-gel Comprising Tetra-PEG Network. Macromolecules 45:3902-3909, 2012

Choi S, Liu I, Yamamoto K, Igawa K, Mochizuki M, Sakai T, Ryosuke E, Honnami M, Suzuki S, Chung U, Sasaki N. Development and evaluation of tetrapod-shaped granular artificial bones. Acta Biomaterialia 8:2340-2347, 2012

Sakai T, Kurakazu M, Akagi Y, Shibayama M, Chung U. Effect of swelling and deswelling on the elasticity of polymer networks in dilute to semi-dilute region. Soft Matter 8:2730-2736, 2012

Ha B,Nagaoka M, Yonezawa T, Tanabe R, Woo J, Kato H, Chung U, Yagasaki K. Regulatory mechanism for the stimulatory action of genistein on glucose uptake in vitro and in vivo. J Nutri Biochem 23:501-509, 2012

Nishi K, Fujii K, Chijiishi M, Katsumoto Y, Chung U, Sakai T, Shibayama M. Kinetic Study for AB-type Coupling Reaction of Tetra-arm Polymers. Macromolecules 45:1031-1036, 2012

Fujii K, Asai H, Ueki T, Sakai S, Imaizumi S, Chung U, Watanabe M, Shibayama M. High-performance ion gel with Tetra-PEG network. Soft Matter 8:1756-1759, 2012

Hirata M, Kugimiya F, Fukai A, Saito T, Yano F, Ikeda T, Mabuchi A, Sapkota B, Akune T, Nishida N, Yoshimura N, Nakagawa T, Tokunaga K, Nakamura K, Chung U, Kawaguchi H. C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes. Hum Mol Genet 21:1111-1123, 2012

Lange F, Schwenke K, Kurakazu M, Akagi Y, Chung U, Lang M, Sommer J, Sakai T, Saalwaechter K. Connectivity and Structural Defects in Tetra-PEG Hydrogels: A Combined Proton NMR and Monte-Carlo Simulation Study Macromolecules 44:9666-9674, 2012

Ito S, Shimohata N, Iwanaga S, Ito W, Ohba M, Mochizuki M, Nakagawa T, Suzuki S, Sasaki N, Koshima I, Chung U. Prevention of intubation-induced mucosal damage using a protective coating with 2-metharcyloyloxyethyl phosphorylcholine polymer. Eur J Aneasthesiol 29:100-104, 2012

Fukai A, Kamekura S, Chikazu D, Nakagawa T, Hirata M, Saito T, Hosaka Y, Ikeda T, Nakamura K, Chung U, Kawaguchi H. Lack of chondroprotective effect of cyclooxygenase-2 inhibition in a mouse surgical osteoarthritis model. Arthritis Rheum 64:198-203, 2012

Choi S, Lee J, Igawa K, Suzuki S, Mochizuki M, Nishimura R, Chung U, Sasaki N. Effect of trehalose coating on basic fibroblast growth factor release from tailor-made artificial bone implant. J Vet Med Sci 73:1547-1552, 2011

Akagi Y, Katashima T, Katsumoto Y, Fujii K, Matsunaga T, Chung U, Shibayama M, Sakai T. Examination of the theories of rubber elasticity using an ideal polymer network. Macromolecules 44:5817-5821, 2011

Yonezawa T, Lee J, Hibino A, Asai M, Hojo H, Ha B,Teruya T, Nagai K, Chung U, Yagasaki K, Woo J. Harmine promotes osteoblast differentiation through bone morphogenetic protein signaling. Biochem Biophys Res Commun 409:260-265, 2011

Ogata N, Shinoda Y, Wettschureck N, Offermanns S, Takeda S, Nakamura K, Segre GV, Chung U, Kawaguchi H. G{alpha}q Signal in Osteoblasts Is Inhibitory to the Osteoanabolic Action of Parathyroid Hormone. J Biol Chem 286:13733-40, 2011

Li X, Tsutsui Y, Matsunaga T, Shibayama M, Chung U, Sakai T. Precise control and prediction of hydrogel degradation behavior. Macromolecules 44:3567-3571, 2011

Fujino H, Lee S, Suzuki S, Chung U, Mochizuki M, Nishimura R, Sasaki N. Trehalose May Prevent Postsurgical Adhesions in a Rabbit Model of Hysterotomy. J Vet Med Sci 73:931-935, 2011

Matsunaga T, Asai H, Akagi Y, Sakai T, Chung U, Shibayama M. SANS Studies on Tetra-PEG Gel under Uniaxial Deformation. Macromolecules 44:1203-1210, 2011

Saijo H, Kanno Y, Mori Y, Suzuki S, Ohkubo K, Chikazu D, Yonehara Y, Chung U, Takato T. A novel method for designing and fabricating custom-made artificial bones. Int J Oral Maxillofac Surg 40:955-960, 2011

Hashimoto Y, Takasu M, Kawamoto S, Oda T, Nagao H, Sakai T, Chung U. Structure and dymanics of tetra-PEG gel by Brownian dynamics. Trans Mater Res Soc Japan 35:547-553, 2010

Sakai T, Matsunaga T, Akagi Y, Kurakazu M, Chung U, Shibayama M. Highly elastic and deformable hydrogel formed from tetra-arm polymers. Macromolecular Rapid Commun 31:1954-1959, 2010

Hojo H, Ohba S, Yano F, Chung U. Coordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development. J Bone Miner Metab 28:489-502, 2010

Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung U, and Kawaguchi H. Transcriptional regulation of endochondral ossification by HIF2A during skeletal growth and osteoarthritis development. Nat Med 16:678-683, 2010

Fukasawa M, Sakai T, Chung U, Haraguchi K. Synthesis and mechanical properties of a nanocomposite gel consisting of a tetra-PEG/clay network. Macromolecules 43:4370-4378, 2010

Mori Y, Yano F, Shimohata S, Suzuki S, Chung U, Takato T. Trehalose inhibits oral xerosis by protecting cell membrane. Int J Oral Maxillofac Surg 36:916-921, 2010

Nakajima K, Komiyama Y, Hojo H, Ohba S, Yano F, Nishikawa N, Aburatani H, Takato T, Chung U. Enhancement of bone formation ex vivo and in vivo by a helioxanthin-derivative. Biochem Biophys Res Commun 395:502-508, 2010

Fröhlich LF, Mrakovcic M, Steinborn S, Chung U, Bastepe M, Jüppner H. Targeted deletion of the Nesp55 DMR provides evidence for another principal imprinting control region within Gnas and a mouse model of autosomal dominant pseudohypoparathyroidism type Ib. Proc Natl Acad Sci USA 107:9275-9280, 2010

Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Ikeda T, Yonezawa T, Woo J, TakatoT, Nakamura K, Kawaguchi H, Chung U. Oxytetracycline induces chondrogenic differentiation without promoting terminal differentiation.J Bone Miner Metab 28:489-502, 2010

Kurakazu M, Katashima T, Chijiishi M, Nishi K, Akagi Y, Matsunaga T, Shibayama M, Chung U, Sakai T. Evaluation of gelation kinetics of Tetra-PEG gel. Macromolecules 43:3935-3940, 2010

Kimura A, Inose H, Yano F, Fujita F, Ikeda T, Sato S, Iwasaki M, Jinno T, Ae K, Fukumoto S, Takeuchi Y, Itoh H, Imamura T, Kawaguchi H, Chung U, Martin JF, Iseki S, Shinomiya K, Takeda S. Runx1 and Runx2 cooperate during sternum morphogenesis. Development 137:1159-1167, 2010.

Akagi Y, Matsunaga T, Shibayama M, Chung U, Sakai T. Evaluation of topological defects in Tetra-PEG gels. Macromolecules 43:488-493, 2010

Wada M, Watanabe S, Chung U, Higo N, Taniguchi T, Kitazawa S. Noninvasive bioluminescence imaging of c-fos expression in the mouse barrel cortex. Behavioural Brain Research 208:158-162, 2010

Fukai A, Kawamura N, Saito T, Oshima Y, Ikeda T, Kugimiya F, Higashikawa H, Yano F, Ogata N, Nakamura K, Chung U, Kawaguchi H. Akt1 in chondrocytes controls cartilage calcification during endochondral ossification under physiological and pathological conditions. Arthritis Rheum 62:826-836, 2010

Shinoda Y, Kawaguchi H, Higashikawa A, Nakamura K, Chung U, and Ogata N. Mechanisms underlying catabolic and anabolic functions of parathyroid hormone on bone by combination of culture systems of mouse cells. J Cell Biochem 109:755-763, 2010

Zhao J, Ohba S, Komiyama Y, Shinkai M, Chung U, Nagamune T. Icariin: A potential osteoconductive compound for bone tissue engineering. Tissue Eng Part A 16:233-243, 2010

Lee S, Miwa Y, Nishimura R, Chung U, Suzuki S, Sasaki N. Effects of trehalose and sodium carboxymethyl cellulose on prevention of organ adhesion after laparotomy: a preclinical study. Jpn J Vet Aneth Surg 40:19-26, 2009

Choi SJ, Lee JI, Igawa K, Sugimori O, Suzuki S, Mochizuki M, Nishimura R, Chung UI, Sasaki N. Bone regeneration within a tailor-made tricalcium phosphate bone implant with both horizontal and vertical cylindrical holes transplanted into the skull of dogs. J Artif Organs. 12:274-277, 2009

Ohba S, Yano F, Chung U. Tissue engineering of bone and cartilage. IBMS BoneKEy 6:405-419, 2009

Matsunaga T, Sakai T, Akagi Y, Chung U, Shibayama M. SANS and SLS Studies on Tetra-Arm PEG Gels in As-prepared and Swollen States. Macromolecules 42:6245-6252, 2009

Saijo H, Kanno Y, Igawa K, Mori Y, Kondo K, Shimizu K, Suzuki S, Chikazu D, Iino M, Sasaki N, Anzai M, Chung U, Takato T. Maxillofacial reconstruction using custom-made artificial bones fabricated by inkjet printing technology. J Artif Organs 12:200-205, 2009

Chung U. Manufacturing of artificial bones using 3D inkjet printing technology. Int J Automation Technology 3:509-513, 2009

Matsunaga T, Sakai T(Co-first), Akagi Y, Chung U, Shibayama M. Structure characterization of Tetra-PEG Gel by Small-angle Neutron Scattering. Macromolecules 42:1344-1351, 2009

Adams GB, Alley IR, Chung U, Chabner KT, Marsters ES, Chen M, Weinstein LS, Kronenberg HM, Scadden DT. Haematopoietic stem cells depend on Gαs-mediated signalling to engraft bone marrow. Nature 459:103-107, 2009

Kan A, Ikeda T, Saito T, Yano F, Ogata N, Nakamura K, Chung U, Kawaguchi H. Screening of Chondrogenic Factors by a Real-Time Fluorescence Monitoring Cell Line ATDC5-C2ER: Identification of Sorting Nexin 19 as a Novel Factor. Arthritis Rheum 60:3314-3323, 2009

Ogasawara T, Ohba S, Fujihara Y, Takahashi T, Liu G, Chikazu D, Suenaga H, Chung U, Yoda T, Mori Y, Susami T, Takato T, Hoshi K. Effects of transforming growth factor (TGF)-b1 in combination with fibroblast growth factor (FGF)-2 and insulin-like growth factor (IGF)-I on chondrocytes proliferation culture for the cartilage regenerative medicine. Asian J Oral Maxillofac Surg 21:18-26, 2009

Liu G, Ogasawara T, Watanabe J, Ishihara K, Asawa K, Chung U, Moro T, Takatori T, Takato T, Nakamura K, Kawaguchi H, Hoshi K. Selection of highly osteogenic and chondrogenic cells from bone marrow stromal cells in biocompatible polymer-coated plates. J Biomed Mater Res A 92A:1273-1282, 2009

Ushita M, Saito T, Ikeda T, Yano F, Higashikawa A, Ogata N, Chung UI, Nakamura K, Kawaguchi H. Transcriptional induction of SOX9 by NF-κB family member RelA in chondrogenic cells. Osteoarthritis Cartilage 17:1065-1075, 2009

Wang W, Itaka K, Ohba S, Nishiyama N, Chung U, Yamasaki Y, Kataoka K. 3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells. Biomaterials 30:2705-15, 2009

Yamamoto K, Igawa K, Ueno H, Yano F, Chung U, Koshima I. Temporal and spatial changes in element distribution in bone and cartilage. J Orthop Sci 14:190-203, 2009

Zhao J, Shinkai M, Takezawa T, Ohba S, Chung U, Nagamune T. Bone Regeneration Using Collagen Type I Vitrigel with Bone Morphogenetic Protein-2. J Biosci Bioeng 107:318-323, 2009

Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Nakamura K, Chung U, Kawaguchi H. Identification of the core element responsive to Runx2 in the promoter of human type X collagen gene. Arthritis Rheum 60:166-178, 2009

Hirata M, Kugimiya F, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Fukai A, Ikeda T, Nakamura K, Chung U, Kawaguchi H. C/EBPβ promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57Kip2. PLoS ONE 4:e4543, 2009

Sakai T, Matsunaga T, Yamamoto Y, Ito C, Yoshida R, Sasaki N, Suzuki S, Shibayama M, Chung U. Design and fabrication of a high-strength hydrogel with ideally homogeneous network structure from tetrahedron-like macromonomers. Macromolecules 41:5379-84, 2008

Saijo H, Chung U, Igawa K, Mori Y, Chikazu D, Iino M, Takato T. Clinical application of artificial bone in the maxillofacial region. J Artif Organs 11:171-6, 2008

Hojo H, Igawa K, Ohba S, Yano F, Nakajima K, Komiyama Y, Ikeda T, Lichtler AC, Woo J-T, Yonezawa T, Takato T, Chung U. Development of high-throughput screening system for osteogenic drugs using a cell-based sensor. Biochem Biophys Res Commun 376:375-379, 2008

Lee S, Hong SW, Choi HS, Lee LY, Nam C, Rhee Y, Chung U, Lim SK. Experimental Parathyroid Hormone Gene Therapy using ØC31 Integrase. Endocr J 55:1033-1041, 2008

Oshima Y, Akiyama T, Hikita A, Iwasawa M, Nagase Y, Nakamura M, Wakeyama H, Kawamura N, Ikeda T, Chung U, Hennighausen L, Kawaguchi H, Nakamura K, Tanaka S. Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis. J Biol Chem 283:26499-26508, 2008

Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung U, Kawaguchi H. Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9. J Biol Chem 283:24682-24689, 2008

Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, Ogata N, Hoshi K, Hofmann F, Woodgett JR, Nakamura K, Chung U, Kawaguchi H. Phosphorylation of GSK-3β by cyclic GMP-dependent protein kinase II promotes chondrocyte hypertrophy and skeletal growth. J Clin Invest 118:2506-2515, 2008

Wu S, Nishiyama N, Kano MR, Morishita Y, Miyazono K, Itaka K, Chung U, Kataoka K. Enhancement of Angiogenesis Through Stabilization of Hypoxia-inducible Factor-1 by Silencing Prolyl Hydroxylase Domain-2 Gene. Mol Ther 16:1227-34, 2008

Ohba S, Kawaguchi H, Kugimiya F, Ogasawara T, Kawamura N, Saito T, Ikeda T, Fujii K, Miyajima T, Kuramochi A, Miyashita T, Oda H, Nakamura K, Takato T, Chung U. Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity. Dev Cell 14:689-699, 2008

Tamiya H, Ikeda T, Jung JH, Saito T, Jung YK, Kawaguchi H, Ohba S, Chung U, and Choi JY: Analysis of the Runx2 promoter in osseous and non-osseous cells and identification of HIF2A as a potent transcriptional activator. Gene 416:53-60, 2008

Yamakawa K, Kamekura S, Kawamura N, Saegusa M, Kamei D, Murakami M, Kudo I, Uematsu S, Akira S, Chung U, Nakamura K, Kawaguchi H. Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders. Arthritis Rheum 58:172-183, 2008

Zhao J, Shinkai M, Ohba S, Chung U, Nagamune T. Icariin induce osteoblastic differentiation in vitro by a BMP and runx2 pathway. Biochem Biophys Res Commun 369:444-448, 2008

Jang K, Sato K, Igawa K, Chung U, Kitamori T. Development of an osteoblast cell-based 3D continuous perfusion microfluidic system for drug screening. Analytical Bioanalytical Chemistry 390:825-832, 2008

Chung U, Itaka K, Nishiyama N, Takato T, Kawaguchi H, Nakamura K, Kataoka K. Scaffolds for skeletal regeneration. NanoBioTechnology 3:104-106, 2007

Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung U, Xavier R, Alt FW, Snapper SB. Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development. Proc Natl Acad Sci USA 104:15424-15429, 2007

Ogata N, Kawaguchi H, Chung U, Roth SI, Segre GV. Continuous activation of Gαq in osteoblasts results in osteopenia through impaired osteoblast differentiation. J Biol Chem 282:35757-35764, 2007

Kawamura N, Kugimiya F, Oshima Y, Ohba S, Ikeda T, Saito T, Shinoda Y, Kawasaki Y, Ogata N, Hoshi K, Akiyama T, Tobe T, Kadowaki T, Azuma Y, Tanaka S, Nakamura K, Chung U, and Kawaguchi H. Akt1 in osteoblasts and osteoclasts controls bone remodeling. PLoS ONE 2:e1058, 2007

Kugimiya F, Kawaguchi H, Ohba S, Kawamura N, Chikuda H, Azuma Y, Woodgett J, Nakamura K, Chung U. GSK-3β controls osteogenesis through regulating Runx2 activity. PLoS ONE 2:e837, 2007

Masago K, Itaka K, Nishiyama N, Chung U, Kataoka K. Gene delivery with biocompatible cationic polymer: Pharmacogenomic analysis on cell bioactivity. Biomaterials 28:5169-5175, 2007

Shimizu S, Asou Y, Itoh S, Chung UI, Kawaguchi H, Shinomiya K, Muneta T. Prevention of cartilage destruction with intraarticular osteoclastogenesis inhibitory factor/osteoprotegerin in a murine model of osteoarthritis. Arthritis Rheum 56:3358-3365, 2007

Itaka K, Ohba S, Chung U, Kataoka K. Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles. Mol Ther 15:1655-1662, 2007

Liu G, Kawaguchi H, Ogasawara T, Asawa Y, Kishimoto JI, Takahashi T, Chung U, Yamaoka H, Asato H, Nakamura K, Takato T, Hoshi K. Optimal combination of soluble factors for tissue engineering of permanent cartilage from cultured human chondrocytes. J Biol Chem. 282:20407-20415, 2007

Ohba S, Nakajima K, Kugimiya F, Igawa K, Itaka K, Moro T, Nakamura K , Kawaguchi H, Takato T, Chung U. A novel compound, TH, induces osteogenic differentiation in a BMP-dependent manner. Biochem Biophys Res Commun 357:854-860, 2007

Ikeda T, Saito T, Ushita M, Yano F, Kan A, Itaka K, Moro T, Nakamura K, Kawaguchi H, Chung U. Identification and characterization of the human SOX6 promoter. Biochem Biophys Res Commun 357:383-390, 2007

Saito T, Ikeda T, Nakamura K, Chung U, Kawaguchi H. S100A1 and B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes. EMBO Rep 8:504-509, 2007

Ohba S, Ikeda T, Kugimiya F, Yano F, Lichtler AC, Nakamura K, Takato T, Kawaguchi H, Chung U. Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell-based sensor. FASEB J 21:1777-1787, 2007

Kosaki N, Kamekura S, Kimura T, Okada Y, Minqi L, Amizuka N, Chung U, Nakamura K, Kawaguchi H, Toyama Y, D'Armiento J, Takaishi H. Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice. Biochem Biophys Res Commun 354:846-851, 2007

Igawa K, Mochizuki M, Sugimori O, Shimizu K, Yamazawa K, Kawaguchi H, Nakamura K, Takato T, Nishimura R, Suzuki S, Anzai M, Chung U, Sasaki N. Tailor-made tricalcium phosphate bone implant directly fabricated by a three-dimensional ink-jet printer. J Artif Organs 9:234-240, 2006

Bounoutas GS, Tawfeek H, Fröhlich LF, Chung U, Abou-Samra AB. Impact of impaired receptor internalization on calcium homeostasis in knock-in mice expressing a phosphorylation-deficient parathyroid hormone (PTH)/PTH-related peptide receptor. Endocrinology 147:4674-4679, 2006

Provot S, Kempf H, Murtaugh C, Chung U, Kim DW, Chyung J, Kronenberg HM, Lassar AB. Nkx3.2/Bapx1 acts as a negative regulator of chondrocyte maturation. Development 133:651-662, 2006.

Kanayama N, Fukushima S, Nishiyama N, Itaka K, Jang W, Miyata K, Yamasaki Y, Chung U, Kataoka K. A PEG-Based Biocompatible Block Catiomer with High Buffering Capacity for the Construction of Polyplex Micelles Showing Efficient Gene Transfer toward Primary Cells. ChemMedChem 1:439-444, 2006

Guo J, Chung U, Yang D, Karsenty G, Bringhurst R, Kronenberg HM. PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways. Dev Biol 292:116-128, 2006

Yamada T, Kawano H, Koshizuka Y, Fukuda T, Yoshimura K, Kamekura S, Saito T, Ikeda T, Kawasaki Y, Azuma Y, Ikegawa S, Hoshi K, Chung U, Nakamura K, Kato S, Kawaguchi H. Carminerin contributes to chondrocyte calcification during endochondral ossification. Nat Med 12:665-670,2 006.

Kugimiya F, Ohba S, Nakamura K, Kawaguchi H, Chung U. Physiological role of bone morphogenetic proteins in osteogenesis. J Bone Miner Metab 24:95-99, 2006

Shinoda Y, Yamaguchi M, Ogata N, Akune T, Kubota N, Yamauchi T, Terauchi Y, Kadowaki T, Takeuchi Y, Fukumoto S, Ikeda T, Hoshi K, Chung U, Nakamura K, Kawaguchi H. Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. J Cell Biochem 99:196-208, 2006

Katagiri M, Ogasawara T, Hoshi K, Chikazu D, Kimoto A, Noguchi M, Sasamata M, Harada S, Akama H, Tazaki H, Chung U, Takato T, Nakamura K, Kawaguchi H. Suppression of adjuvant-induced arthritic bone destruction by cyclooxygenase-2 selective agents with and without inhibitory potency against carbonic anhydrase II. J Bone Miner Res 21:219-227, 2006

Yamaoka H, Asato H, Ogasawara T, Nishizawa S, Takahashi T, Nakatsuka T, Koshima I, Nakamura K, Kawaguchi H, Chung U, Takato T, Hoshi K. Cartilage tissue engineering using human auricular chondrocytes embedded in different hydrogel materials. J Biomed Mater Res A 78:1-11, 2006

Kamekura S, Kawasaki Y, Hoshi K, Shimoaka T, Chikuda H, Maruyama Z, Komori T, Sato S, Takeda S, Karsenty G, Nakamura K, Chung U, Kawaguchi H. Contribution of runt-related transcription factor 2 to pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum 54:2462-2470, 2006

Zhao B, Katagiri T, Toyoda H, Takada T, Yanai T, Fukuda T, Chung U, Koike T, Takaoka K, Kamijo R. Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-2. J Biol Chem 281:23246-23253, 2006

Yano F, Kugimiya F, Ohba S, Ikeda T, Chikuda H, Ogasawara T, Ogata N, Takato T, Nakamura K, Kawaguchi H, Chung U. The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner. Biochem Biophys Res Commun 333:1300-1308, 2005

Kugimiya F, Kawaguchi H, Kamekura S, Chikuda H, Ohba S, Yano F, Ogata N, Katagiri T, Harada Y, Azuma Y, Nakamura K, Chung U. Involvement of endogenous bone morphogenetic protein (BMP)2 and BMP6 in bone formation. J Biol Chem 280:35704-35712, 2005

Kugimiya F, Yano F, Ohba S, Igawa K, Nakamura K, Kawaguchi H, Chung U. Mechanism of osteogenic induction by FK506 via BMP/Smad pathways. Biochem Biophys Res Commun 338:872-879, 2005

Moro T, Ogasawara T, Chikuda H, Ikeda T, Ogata N, Maruyama Z, Komori T, HoshiK, Chung U, Nakamura K, Okayama H, Kawaguchi K. Inhibition of Cdk6 expression through p38 MAP kinase is involved in differentiation of mouse prechondrocyte ATDC5. J Cell Physiol 204:927-933, 2005

Yamaguchi M, Ogata N, Shinoda Y, Akune T, Kamekura S, Terauchi Y, Kadowaki T, Hoshi K, Chung U, Nakamura K, Kawaguchi H. Insulin receptor substrate-1 is required for bone anabolic function of parathyroid hormone in mice. Endocrinology 146:2620-2628, 2005

Chikuda H, Kugimiya F, Hoshi K, Ikeda T, Ogasawara T, Kamekura S, Ogata N, Nakamura K, Chung U, Kawaguchi H. Mutation in cGMP-dependent protein kinase II causes dwarfism in a rat mutant KMI through uncoupling of proliferation and differentiation of chondrocytes. J Bone Miner Metab 23:200-204, 2005

Kawaguchi H, Akune T, Yamaguchi M, Ohba S, Ogata N, Chung U, Kubota N, Terauchi Y, Kadowaki T, Nakamura K. Distinct effects of PPARgamma insufficiency on bone marrow cells, osteoblasts, and osteoclastic cells. J Bone Miner Matab 23:275-279, 2005

Kamekura S, Hoshi K, Shimoaka T, Chung U, Chikuda H, Yamada T, Uchida M, Ogata N, Seichi A, Nakamura K, Kawaguchi H. Osteoarthritis development in novel experimental mouse models induced by knee joint instability. Osteoarthritis Cartilage 13:632-641, 2005

Ikeda T, Kawaguchi H, Kamekura S, Ogata N, Mori Y, Nakamura K, Ikegawa S, Chung U. Distinct roles of Sox5, Sox6, and Sox9 in different stages of chondrogenic differentiation. J Bone Miner Metab 23:337-340, 2005

Lee S, Hwang R, Lee J, Rhee Y, Kim DJ, Chung U, Lim S-K. Ectopic expression of vasopressin V1b and V2 receptors in the adrenal glands of familial ACTH-independent macronodular adrenal hyperplasia. Clin Endocrinol (Oxf) 63:625-630, 2005

Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Hoshi K, Ogasawara T, Nakamura K, Chung U, Kawaguchi H. Involvement of cyclic guanosine monophosphate-dependent protein kinase II in chondrocyte hypertrophy during endochondral ossification. Mod Rheumatol 15:391-396, 2005

Takahashi T, Ogasawara T, Kishimoto J, Liu G, Asato H, Nakatsuka T, Uchimura T, Nakamura K, Kawaguchi H, Chung U, Takato T, Hoshi K. Synergistic effects of FGF-2 with insulin or IGF-I on the proliferation of human auricular chondrocytes. Cell Transplant 14:683-693, 2005

Bastepe M, Weinstein LS, Ogata N, Kawaguchi H, Jüppner H, Kronenberg HM, Chung U. Stimulatory G protein (Gs) directly regulates hypertrophic differentiation of growth plate cartilage in vivo. Proc Natl Acad Sci USA 101:14794-14799, 2004

Ikeda T, Kamekura S, Mabuchi A, Kou I, Seki S, Takato T, Nakamura K, Kawaguchi H, Ikegawa S, Chung U. The combination of SOX5, SOX6 and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. Arthritis Rheum 50:3561-3573, 2004

Chikuda H, Kugimiya F, Hoshi k, Ikeda T, Ogasawara T, Shimoaka T, Kawano H, Kamekura S, Tsuchida A, Yokoi N, Nakamura K, Komeda K, Chung U, Kawaguchi H. Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes. Genes Dev 18:2418-2429, 2004

Chung U. Essential role of hypertrophic chondrocytes in endochondral bone development. Endocr J 51:19-24, 2004

Moro T, Takatori Y, Ishihara K, Konno T, Takigawa Y, Matsushita T, Chung U, Nakamura K, Kawaguchi H. Surface grafting of artificial joints with a biocompatible polymer for preventing periprosthetic osteolysis. Nat Mater 3:829-836, 2004

Hoshi K, Ogata N, Shimoaka T, Terauchi Y, Kadowaki T, Kenmotsu S, Chung U, Ozawa H, Nakamura K, Kawaguchi H. Deficiency of insulin receptor substrate-1 impairs skeletal growth through early closure of epiphyseal cartilage. J Bone Miner Res 19:214-223, 2004

Long F, Chung U (Co-first), Ohba S, McMahon J, Kronenberg HM, McMahon AP. Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131:1309-1318, 2004

Seto H, Kamekura S, Miura T, Yamamoto A, Chikuda H, Ogata T, Hiraoka H, Oda H, Nakamura K, Kurosawa H, Chung U, Kawaguchi H, Tanaka S. Distinct roles of Smad pathways and p38 pathways in cartilage-specific gene expression in synovial fibroblasts. J Clin Invest 113:718-726, 2004

Shimoaka T, Kamekura S, Chikuda H, Hoshi K, Chung U, Akune T, Maruyama Z, Komori T, Matsumoto M, Ogawa W, Terauchi Y, Kadowaki T, Nakamura K, Kawaguchi H. Impairment of bone healing by insulin receptor substrate-1 deficiency. J Biol Chem 279:15314-15322, 2004

Akune T, Ohba S, Kamekura S, Yamaguchi M, Chung U, Kubota N, Terauchi Y, Harada Y, Azuma Y, Nakamura K, Kadowaki T, Kawaguchi H. PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 113:846-855, 2004

Chung U, Kawaguchi H, Takato T, Nakamura K. Distinct osteogenic mechanisms of bones of distinct origins. J Orthop Sci 9:410-414, 2004

Yamada T, Kawano H, Sekine K, Matsumoto T, Fukuda T, Azuma Y, Itaka K, Chung U, Chambon P, Nakamura K, Kato S, Kawaguchi H. SRC-1 is necessary for skeletal responses to sex hormones in both males and females. J Bone Miner Res 19:1452-1461, 2004

Koshizuka Y, Yamada T, Hoshi K, Ogasawara T, Chung U, Kawano H, Nakamura Y, Nakamura K, Ikegawa S, Kawaguchi H. Cystatin 10, a novel chondrocyte-specific protein, may promote the last step of the chondrocyte differentiation pathway. J Biol Chem 278:48259-48266, 2003

Akiyama T, Bouillet P, Miyazaki T, Kadono Y, Chikuda H, Chung U, Fukuda A, Hikita A, Seto H, Okada T, Inaba T, Sanjay A, Baron R, Kawaguchi H, Oda H, Nakamura K, Strasser A, Tanaka S. Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO J 22:6653-6664, 2003

Guo J, Chung U, Kondo H, Bringhurst FR, Kronenberg HM. The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C. Dev Cell 3:183-194, 2002

Kobayashi T, Chung U, Schipani E, Starbuck M, Karsenty G, Katagiri T, Goad DL, Lanske B, Kronenberg HM. PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps. Development 129:2977-2986, 2002

Kronenberg HM, Chung U. The parathyroid hormone-related protein and Indian hedgehog feedback loop in the growth plate. Novartis Found Symp. 232:144-157, 2001

Huang W, Chung U, Kronenberg H, de Crombrugghe B. The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones. Proc Natl Acad Sci USA 98:160-165, 2001

Chung U, Schipani E, McMahon AP, Kronenberg H. Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J Clin Invest 107:295-304, 2001

Ramirez MI, Chung U, Williams MC. Aquaporin-5 expression, but not other peripheral lung marker genes, is reduced in PTH/PTHrP receptor null mutant fetal mice. Am J Respir Cell Mol Biol 22:367-372, 2000

Watson PH, Fraher LJ, Hendy GN, Chung U, Kisiel M, Natale BV, Hodsman AB. Nuclear localization of the type 1 PTH/PTHrP receptor in rat tissues. J Bone Miner Res 15:1033-1034, 2000

Chung U, Kronenberg HM. Parathyroid hormone-related peptide and Indian hedgehog. Curr Opin Nephrol Hypertens 9:357-362, 2000

Verheijen MH, Karperien M, Chung U, van Wijuen M, Heystek H, Hendricks JA, Veltmaat JM, Lanske B, Li E, Lowik CW, de Laat SW, Kronenberg HM, Defize LH. Parathyroid hormone-related peptide (PTHrP) induces parietal endoderm formation exclusively via the type I PTH/PTHrP receptor. Mech Dev 81:151-161, 1999

Kronenberg HM, Lanske B, Kovacs CS, Chung U, Lee K, Segre GV, Schipani E, Jüppner H. Functional analysis of the PTH/PTHrP network of ligands and receptors. Recent Prog Horm Res 53:283-303, 1998

Chung U, Lanske B, Lee K, Li E, Kronenberg H. The parathyroid hormone/parathyroid hormone-repated peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation. Proc Natl Acad Sci USA 95:l3030-l3035, 1998

Hirakata M, Kaname S, Chung U, Joki N, Hori Y, Noda M, Takuwa Y, Okazaki T, Fujita T, Katoh T, Kurokawa K. Tyrosine kinase dependent expression of TGF-beta induced by stretch in mesangial cells. Kidney Int 51:1028-1036, 1997

Chung U, Igarashi T, Nishishita T, Iwanari H, Iwamatsu A, Suwa A, Mimori T, Hata K, Ebisu S, Ogata E, Fujita T, Okazaki T. The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium. J Biol Chem 271:8593-8598, 1996

Chung U, Tanaka Y, Fujita T. Association of interleukin-6 and hypoaldosteronism in patients with cancer. N Engl J Med 334: 473, 1996

Okazaki T, Chung U, Nishishita T, Ebisu S, Usuda S, Mishiro S, Xanthoudakis S, Igarashi T, Ogata E. A redox factor protein, ref1, is involved in negative gene regulation by extracellular calcium. J Biol Chem 269:27855-27862, 1994

Chung U, Oka M, Nakagawa Y, Nishishita T, Sekine N, Tanaka Y, Harada S, Igarashi T, Ogata E. A patient with protein-losing enteropathy associated with systemic lupus erythematosus. Intern Med 31:521-524, 1992

著書

鄭雄一 「バイオマテリアルの三次元造形」 In:「細胞の3次元組織化-その最先端技術と材料技術」田畑泰彦編(株式会社メディカルドゥ)、2014

鄭雄一「東大理系教授が考える道徳のメカニズム」、KKベストセラーズ、2013

鄭雄一、石井直方『今から始める「寝たきりにならない体」のつくり方』、三笠書房、2013

Chung U, Saijoh H, Igawa K, Kanno Y, Mori Y, Takato T. Three-dimensional shape control of implant devices. In: The Handbook of Intelligent Scaffold for Regenerative Medicine, ed. Gilson Khang (Pan Stanford Publishing), 2012.

鄭雄一『老いない体をつくる「骨の力」』(単著)、主婦の友社、2011

鄭雄一『図解 骨博士が教える「老いない体」のつくり方 実践編』(単著)、ワック株式会社、2011

鄭雄一 『骨博士が教える「老いない体」のつくり方』(単著) ワック株式会社、2010

井川和代、鄭雄一 「セラミック三次元材料」 In:「生体材料」(社)日本セラミックス協会編(日刊工業新聞社)、p.108-114, 2008.

大庭伸介、鄭雄一 「組織再生誘導と分子シグナルの最適化」 In:「ティッシュ・エンジニアリング2007」田畑泰彦、岡野光夫監修(日本医学館)、p.96-99, 2007.

鄭雄一 「テーラーメード人工骨の開発」 In:「最新インクジェット技術」【2007年度版】(技術情報協会)、p.381-393, 2007

鄭雄一 「骨軟骨再生治療デバイス研究開発におけるTRの試み」 In:「医療経営イニシアティブ」木村廣道監修(かんき出版)、p.153-162, 2007

鄭雄一 「ティッシュ・エンジニアリング」 In:「臨床生命情報学入門」山崎力、小山博史、小野木雄三編集(杏林図書)、p.120-129, 2006.

大庭伸介、井川和代、中村耕三、川口浩、高戸毅、鄭雄一 「骨・軟骨の再生医療」 In:「老年医学Update 2005-2006」日本老年医学会雑誌編集委員会編集(メジカルビュー社)、p.199-206, 2005

河村直洋、鄭雄一 「骨の成長を司るシグナル-軟骨内骨化と結合織内骨化-」 In:「骨研究がわかる」高柳広編集(羊土社)、p.32-40, 2005.

松原全宏、川口浩、高戸毅、中村耕三、鄭雄一 「骨の再生」 In:「図解再生医療工学」、立石哲也、田中順三編著(工業調査会) p.123-129, 2004.

緒方直史、川口浩、中村耕三、高戸毅、鄭雄一 「再生医療の老年医学への応用」 In:「老年医学Update 2004-2005」日本老年医学会雑誌編集委員会編集(メジカルビュー社)、p.34-43, 2004

亀倉暁、鄭雄一 「骨はどのようにして形成されるか?」 In:「新しい透析骨症」深川雅史編集(日本メディカルセンター) p.307-311, 2003.

鄭雄一 「PTHrPの生理作用」 In:「PTH/PTHrPの基礎と臨床」池田恭治、福本誠二編集(医薬ジャーナル社) p.112-116, 2002.

Chung U, Kronenberg H. Role of parathyroid hormone-related protein and Indian hedgehog in skeletal development. In: Skeletal Growth Factors, ed. Ernesto Canalis (Lippincott, Williams & Wilkins), p.355-364, 2000.

和文総説

鄭雄一「3Dプリンター人工骨」臨床整形外科 49:1080-1083,2014

大庭伸介・鄭雄一「骨形成シグナルの解明と人工骨の開発」クリニカル・カルシウム 23:31-38,2013

北條宏徳、鄭雄一、大庭伸介「ヘッジホッグシグナル」骨粗鬆症治療 12:1-4,2013

菅家康介、大庭伸介、鄭雄一「骨・軟骨形成の分子基盤と再生医療」細胞 45:5-8,2013

鄭雄一「インクジェットプリンターによるカスタムメイド人工骨」内分泌・糖尿病・代謝内科 32:305-310, 2011.

北條宏徳、大庭伸介、鄭雄一「軟骨内骨化におけるヘッジホッグシグナルの役割」細胞工学 30:238-242, 2011.

大庭伸介、鄭雄一「再医療とDDS」Drug Delivery System 26:46-51, 2011.

大庭伸介・鄭雄一「骨・軟骨領域における再生医学の現状と展望」BioClinica 25:32-35,2010

井川和代、鄭雄一 「三次元プリンティングを用いた人工骨の現状と展望」クリニカル・カルシウム 18:63-69, 2008.

井川和代、鄭雄一 「インテリジェント化材料」化学 63:28-29, 2008.

井川和代、鄭雄一 「三次元高機能足場の構築」日本臨床 66:820-823, 2008.

鄭雄一 「インクジェットプリンターで作るカスタムメイド人工骨」未来材料 7:48-52, 2008.

川崎洋介、鄭雄一、中村耕三、川口浩 「軟骨代謝研究の最近の進歩」クリニカル・カルシウム 16:1730-1735, 2006.

斉藤琢、鄭雄一、池田敏之 「SOX」骨粗鬆症治療 5:70-73, 2006.

東川晶郎、川口浩、中村耕三、鄭雄一 「軟骨内骨化における軟骨細胞と骨芽細胞の相互作用」クリニカル・カルシウム 16:829-836, 2006.

位高啓史、鄭雄一、片岡一則 「ナノキャリアによる遺伝子・siRNAデリバリー」日本臨床 64:253-257, 2006.

釘宮典孝、高戸毅、川口浩、中村耕三、鄭雄一 「BMP遺伝子改変動物」日本臨床 63:414-417, 2005.

鄭雄一、星和人、高戸毅 「再生医療 骨軟骨の再生医療」 現代医療 36:39-44, 2004

鄭雄一、池田敏之、川口浩、中村耕三、高戸毅 「骨・軟骨分化決定因子の解析から再生医学へ」分子リウマチ 1:94-98, 2004.

篠田裕介、緒方直史、高戸毅、川口浩、中村耕三、鄭雄一 「動物の進化とPTH、PTHrP」THE BONE 18:479-483, 2004.

大庭伸介、井川和代、中村耕三、川口浩、高戸毅、鄭雄一 「骨軟骨の再生医療」日本老年医学会雑誌 41:582-588, 2004.

川口浩、鄭雄一、星和人「移植による骨軟骨再生」治療学 38:1120-1127, 2004.

鄭雄一、星和人、川口浩、中村耕三 「分子生物学的アプローチによる骨・軟骨再生」東日本整形災害外科学会雑誌 16:182-184, 2004.

篠田裕介、緒方直史、川口浩、鄭雄一 「骨のremodelingに関する最近の話題」クリニカル・カルシウム 14:70-74, 2003.

釘宮典孝、鄭雄一、川口浩 「BMPと骨形成」クリニカル・カルシウム 14:173-179, 2003.

矢野文子、川口浩、中村耕三、高戸毅、鄭雄一、緒方直史 「PTH/PTHrP受容体」 骨粗鬆症治療3:326-332, 2004.

大庭伸介、鄭雄一 「PTHrPの生理作用」腎と骨代謝 16:131-141, 2003.

釘宮典孝、鄭雄一 「PTHrP、Ihhシグナルと軟骨形成」 Molecular Medicine 40:684-689, 2003.

川口浩、鄭雄一、星和人 「骨軟骨再生研究の分子医学的展望」 Molecular Medicine 40:702-710, 2003.

大庭伸介、鄭雄一 「ヘッジホッグと軟骨細胞」 腎と骨代謝 16:229-236, 2003.

矢野文子、山田高嗣、鄭雄一 「内分泌領域の骨・軟骨関連疾患病態モデル」ホルモンと臨床 51:883-893, 2003.

鄭雄一、星和人、川口浩、中村耕三 「運動器疾患の再生医学の現状と将来展望」リウマチ科 30:403-408, 2003.

釘宮典孝、鄭雄一 「PTH/PTHrPの軟骨形成調節作用」Clinical Calcium 13:19-24, 2002.

鄭雄一 「内軟骨性骨化に関与する分子」Medical Practice 19:1704-1705, 2002.

鄭雄一 「PTHの新しい受容体」 クリニカル・カルシウム 8:641-643,1998.

鄭雄一 「キメラ法による軟骨細胞におけるPTH/PTHrPレセプターの役割の解析」 Molecular Medicine 35:486-490, 1998.

鄭雄一、岡崎具樹、五十嵐徹也「副甲状腺ホルモンの合成、分泌調節」 実験医学 10:533-539, 1992.