Hojo/Tei Group

Research

1. Skeletal development and metabolism

Our primary focus is on the transcriptional regulation of genes which are involved in the differentiation and maturation of osteoblasts and chondrocytes. We are combining genome-wide approach with mouse genetics, biochemistry, and molecular biology to study those biological processes.

Ongoing projects:

Genome-wide analyses to understand mechanisms of transcriptional events in osteoblasts and chondrocytes.

2. Clinical application of basic findings

We try to develop osteogenic and chondrogenic small compounds, and bio-compatible medical materials. Our goal is to establish tissue regeneration system for bone and cartilage defects as well as novel strategies for the treatment of osteoporosis and cartilage degeneration.

Ongoing projects:

  • Development of screening systems for osteogenic and chondrogenic factors.
  • Identification of osteogenic and chondrogenic compounds through the screening of small compound libraries
  • Development of implant devises for skeletal tissue regeneration

Collaborators

University of Southern California Keck School of Medicine

University of Connecticut Health Center

National Institute of Health

Massachusetts General Hospital

Tokyo Dental College

Ritsumeikan University

Okayama University