1. Skeletal development and metabolism
Our primary focus is on the transcriptional regulation of genes which are involved in the differentiation and maturation of osteoblasts and chondrocytes. We are combining genome-wide approach with mouse genetics, biochemistry, and molecular biology to study those biological processes.
Ongoing projects:
Genome-wide analyses to understand mechanisms of transcriptional events in osteoblasts and chondrocytes.
2. Clinical application of basic findings
We try to develop osteogenic and chondrogenic small compounds, and bio-compatible medical materials. Our goal is to establish tissue regeneration system for bone and cartilage defects as well as novel strategies for the treatment of osteoporosis and cartilage degeneration.
Ongoing projects:
Collaborators
University of Southern California Keck School of Medicine
University of Connecticut Health Center
National Institute of Health
Massachusetts General Hospital
Tokyo Dental College
Ritsumeikan University
Okayama University