2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003
Before 2002 | Books

2014

Ohba *: corresponding author

  • Ohba S*, Chung UI: PTHrP action on skeletal development: a key for the controlled growth of endochondral bones. Clinc Rev Bone Miner Metab (in press)
  • Ha BG, Yonezawa T, Son MJ, Woo JT, Ohba S, Chung UI, Yagasaki K: Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. BioFactors (in press)
  • Honnami M, Choi S, Liu IL, Kamimura W, Taguchi T, Hojo H, Shimohata N, Ohba S, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M: Bone regeneration by the combined use of tetrapod-shaped calcium phosphate granules with basic fibroblast growth factor-binding ion complex gel in canine segmental radial defects. J Vet Med Sci (in press)
  • Kanke K, Masaki H, Saito T, Komiyama Y, Hojo H, Nakauchi H, Lichtler AC, Takato T, Chung UI, Ohba S*: Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free conditions. Stem Cell Rep 2(6):751-760, 2014.
  • Choi S, Liu I, Yamamoto K, Honnami M, Sakai T, Ohba S, Echigo R, Suzuki S, Chung UI, Sasaki N, Mochizuki M: Implantation of tetrapod-shaped granular artificial bones or β-tricalcium phosphate granules in a canine large bone?defect model. J Vet Med Sci 76(2):229-235, 2014.
  • Choi S, Honnami M, Liu I, Yamamoto K, Ohba S, Echigo R, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M: Cranioplasty with custom-made artificial bone after resection of multilobular bone tumor in a dog. J Vet Clin 31(1):46-50, 2014.

Tei/Chung 　

  • Okada K, Fukai A, Mori D, Hosaka Y, Yano F, Chung U, Kawaguchi H, Tanaka S, Ikeda T, Saito T. Identification of SCAN domain zinc-finger gene ZNF449 as a novel factor of chondrogenesis. PLoS One 9:e115169, 2014.
  • Kitaura Y, Hojo H, Komiyama Y, Takato T, Chung UI, Ohba S, Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice. PLoS ONE 9(10):e109597, 2014.
  • Choi S, Liu IL, Yamamoto K, Honnami M, Ohba S, Echigo R, Sakai T, Igawa K, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M. Comparison of the long-term effects on rabbit bone defects between TetraboneR and β-tricalcium phosphate granules implantation. J Artif Organ 17:344-351, 2014.
  • Li X, Kondo S, Chung U, Sakai T. Degradation Behavior of Polymer Gels Caused by Non-specific Cleavages of Network Strands. Chem Mater 26:5352-5357, 2014.
  • Yano F, Ohba S, Hosaka Y, Saito T, Chung U. Disease-modifying effects of TD-198946 on progressed osteoarthritis in a mouse model. Ann Rheum Dis 73:2062-4, 2014.
  • Mori Y, Chung U, Tanaka S, Saito T. Determination of differential gene expression profiles in superficial and deeper zones of mature rat articular cartilage using RNA sequencing of laser microdissected tissue specimens. Biomed Res 35(4):263-70, 2014.
  • Mori Y, Mori D, Chung U, Tanaka S, Heierhorst J, Buchou T, Baudier J, Kawaguchi H, Saito T. S100A1 and S100B are dispensable for endochondral ossification during skeletal development. Biomed Res 35(4):243-50, 2014.
  • Kanke K, Masaki H, Saito T, Komiyama Y, Hojo H, Nakauchi H, Lichtler AC, Takato T, Chung UI, Ohba S. Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free condition. Stem Cell Reports 2:751-760, 2014.
  • Ha BG1, Yonezawa T, Son MJ, Woo JT, Ohba S, Chung UI, Yagasaki K. Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. BioFactors 40:436-47, 2014.
  • Mori Y, Saito T, Chang SH, Kobayashi H, Ladel CH, Guehring H, Chung U, Kawaguchi H. Identification of fibroblast growth factor-18 as a molecule to protect adult articular cartilage by gene expression profiling. J Biol Chem 289(14):10192-200, 2014.
  • Choi S, Honnami M, Liu I, Yamamoto K, Ohba S, Echigo R, Suzuki S, Nishimura R, Chung U, Sasaki N, Mochizuki M. Cranioplasty with Custom-made Artificial Bone after Resection of Multilobular Bone Tumor in a Dog. J Vet Clin 31:46-50, 2014.
  • Kamata H,Akagi Y,Kayasuga-Kariya Y, Chung U, Sakai T. Non-swellable hydrogel without mechanical hysteresis. Science 343:873-875, 2014.
  • Katashima T, Asai M, Urayama L, Chung U, Sakai T. Mechanical properties of Tetra-PEG gels with supercoiled network structure. J Chem Phys 140:074902, 2014.
  • Elgali I, Igawa K, Palmquist A, Lenneras M, Xia W, Choi S, Chung U, Omar O, Thomsen P. Molecular and structural patterns of bone regeneration in surgically created defects containing bone substitutes. Biomaterials 35:3229-3242, 2014.
  • Kondo S, Chung U, Sakai T. Effect of prepolymer architecture on the network structure formed by AB-type crosslink-coupling. Polymer J 46:14-20, 2014.
  • Choi S, Liu I, Yamamoto K, Honnami M, Sakai T, Ohba S, Echigo R, Suzuki S, Nishimura R, Chung U, Sasaki N, Mochizuki M. Implantation of Tetrapod-shaped Granular Artificial Bones or β-Tricalcium Phosphate Granules in a Canine Large Bone-Defect Model. J Vet Med Sci 76:229-235, 2014.
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2013

Ohba *: corresponding author

  • Zhang X, Peterson KA, Liu XS, McMahon AP, Ohba S (co-first): Gene regulatory networks mediating canonical Wnt signal directed control of pluripotency and differentiation in embyo stem cells. Stem Cells 31:2667-2679, 2013.
  • Maeda Y, Hojo H, Shimohata N, Choi S, Yamamoto K, Takato T, Chung UI, Ohba S*: Bone healing by sterilizable calcium phosphate tetrapods eluting osteogenic molecules. Biomaterials 34(22):5530-5537, 2013.
  • Komiyama Y, Ohba S*, Shimohata N, Nakajima K, Hojo H, Yano F, Takato T, Docheva D, Shukunami C, Hiraki Y, Chung UI: Tenomodulin expression in the periodontal ligament enhances cellular adhesion. PLoS ONE 8(4): e60203, 2013.
  • Hojo H, Ohba S*, Taniguchi K, Shirai M, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Mishina Y, Yamada M, Konno T, Takato T, Kawaguchi H, Kambara H, Chung UI: Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium. J Biol Chem 288(14):9924-9932, 2013.
  • Saito T, Saito T, Yano F, Mori D, Ohba S, Hojo H, Otsu M, Eto K, Nakauchi H, Tanaka S, Chung UI, Kawaguchi H: Generation of Col2a1-EGFP iPS cells for monitoring chondrogenic differentiation. PLoS ONE 8(9):e74137, 2013.
  • Honnami M, Choi S, Liu I, Kamimura W, Taguchi T, Hojo H, Shimohata N, Ohba S, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M: Repair of rabbit segmental femoral defects by using a combination of tetrapod-shaped granular artificial bones and basic fibroblast growth factor-binding ion complex gel. Biomaterials 34(36):9056-9062, 2013.
  • Yano F, Hojo H, Ohba S, Saito T, Honnami M, Mochizuki M, Takato T, Kawaguchi H, Chung UI: Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration. Biomaterials 34(22):5581-5587, 2013.
  • Yano F, Hojo H, Ohba S, Fukai A, Hosaka Y, Ikeda T, Saito T, Hirata M, Chikuda H, Takato T, Kawaguchi H, Chung UI: A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis 72(5):748-753, 2013.
  • Wu S, Kasim V, Kano MR, Tanaka, S, Ohba S, Miura Y, Miyata K, Liu X, Matsuhashi A, Chung UI, Yang L, Kataoka K, Nishiyama N, Miyagishi M: Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1&alpha in a p53-independent manner. Cancer Res 73(6):1787-1799, 2013.
  • Ogasawara T, Ohba S, Yano F, Kawaguchi H, Chung UI, Saito T, Yonehara Y, Nakatsuka T, Mori Y, Takato T, Hoshi K: Nanog promotes osteogenic differentiation of the mouse mesenchymal cell line　C3H10T1/2 by modulating bone morphogenetic protein (BMP) signaling. J Cell Physiol 228(1):163-171, 2013.

Tei/Chung 　

  • Li X, Khairulina K, Chung U, Sakai T. Migration behavior of rod-like dsDNA under electric field in homogeneous polymer networks.　Macromolecules 46:8665-8663, 2013.
  • Takehara H, Nagaoka A, Noguchi J, Akagi T, Sakai T, Chung U, Kasai H, Ichiki T. Implementation of tetra-poly(ethylene glycol) hydrogel with high mechanical strength into microfluidic device technology. Biomicrofluidics 7:054109, 2013.
  • Akagi Y, Sakurai H, Gong JP, Chung U, Sakai T. Fracture energy of polymer gels with controlled network structures. J Chem Phys 139:144905, 2013.
  • Nakajima T, Fukuda Y, Kurokawa T, Sakai T, Chung U, Gong JP. Synthesis and Fracture Process Analysis of Double Network Hydrogels with a Well-Defined First Network. ACS Macro Letters 2:518-521, 2013.
  • Kobayashi H, Hirata M, Saito T, Itoh S, Chung UI, Kawaguchi H.　Transcriptional induction of ADAMTS5 by an NF-κB family member RelA/p65 in chondrocytes during osteoarthritis development. J Biol Chem 288:28620-28629, 2013.
  • Honnami M, Choi S,Liu I, Kamimura W, Taguchi T, Ichimura M, Urushizaki Y, Hojo H, Shimohata N, Ohba S, Amaya K, Koyama H, Nishimura R, Chung U, Sasaki N, Mochizuki M. Repair of rabbit segmental femoral defects by using a combination of tetrapod-shaped calcium phosphate granules and basic fibroblast growth factor-binding ion complex gel. Biomaterials 34:9056-9062, 2013.
  • Saito T, Yano F, Mori D, Ohba S, Hojo H, Otsu M, Eto K, Nakauchi H, Tanaka S, Chung U, Kawaguchi H. Generation of Col2a1-EGFP iPS cells for monitoring chondrogenic　differentiation. PLoS ONE 8:e74137, 2013.
  • Kayasuga-Kariya Y, Iwanaga S, Fujisawa A, Lin L, Suzuki S, Chung U, Shimohata N, Mochizuki M. Dermal cell damage induced by topical application of non-steroidal anti-inflammatory drugs is suppressed by trehalose co-lyophilization in ex vivo analysis. J Vet Med Sci 75:1619-1622,2013.
  • Cabral H, Murakami M, Hojo H, Terada Y, Kano MR, Chung U, Nishiyama N, Kataoka K. Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis. Proc Natl Acad Sci USA 110:11397-11402, 2013
  • Yano F, Hojo H, Ohba S, Saito T, Honnami M, Mochizuki M, Takato T, Kawaguchi H, Chung U. Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration. Biomaterials 34:5581-5587, 2013.
  • Akagi Y, Gong JP, Chung U, Sakai T. Transition between Phantom and Affine Network Model Observed in Polymer Gels with Controlled Network Structure. Macromolecules 46:1035-1040, 2013.
  • Maeda Y, Hojo H, Shimohata N, Choi S, Yamamoto K, Takato T, Chung U, Ohba S. Bone healing by sterilizable calcium phosphate tetrapods eluting osteogenic molecules. Biomaterials 34:5530-5537, 2013.
  • Komiyama Y, Ohba S, Shimohata N, Nakajima K, Hojo H, Yano F, Takato T, Docheva D, Shukunami C, Hiraki Y, Chung U. Tenomodulin expression in the periodontal ligament enhances cellular adhesion. PLoS ONE 8:e60203, 2013.
  • Hojo H, Ohba S, Taniguchi K, Shirai S, Yano F,Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N,Suzuki K, Mishina M, Yamada M, Konno T, Takato T,Kawaguchi H, Kambara H, Chung U. Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium. J Biol Chem 288:9924-9932, 2013.
  • Kan A, Ikeda T, Fukai A, Nakagawa T, Nakamura K, Chung U, Kawaguchi H, Tabin CJ. SOX11 contributes to the regulation of GDF5 in joint maintenance. BMC Dev Biol 13:4, 2013.
  • Wu S, Kasim V, Kano MR, Tanaka S, Ohba S, Miura Y, Miyata K, Liu X, Matsuhashi A, Chung U, Yang L, Kataoka K, Nishiyama N, Miyagishi M. Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner. Cancer Res 73:1787-1799, 2013.
  • Choi S, Lee J, Igawa K, Liu I, Honnami M, Suzuki S, Nishimura R, Chung U, Sasaki N, Mochizuki M. Changes in bone regeneration by trehalose coating and basic fibroblast growth factor after implantation of tailor-made bone implants in dogs. J Vet Med Sci 75:721-726, 2013.
  • Hosaka Y, Saito T, Sugita S, Hikata T, Kobayashi H, Fukai A, Taniguchi Y, Hirata M, Akiyama H, Chung U, Kawaguchi H. Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development. Proc Natl Acad Sci USA 110:1875-1880, 2013.
  • Yano F, Saito T (contributed equally),Ogata N, Yamazawa T, Iino M, Chung U, Kawaguchi H. β-catenin regulates PTH/PTHrP receptor signals and chondrocyte hypertrophy through binding to its intracellular C-terminal region. Arthritis Rheum 65:429-35, 2013.
  • Yamauchi H, Motomura N, Chung U, Sata M, Takai D, Saito A, Ono M, Takamoto S. Growth-associated hyperphosphatemia in young recipients accelerates aortic allograft calcification in a rat model. J Thorac Cardiovasc Surg 145:522-530, 2013.
  • Ogasawara T, Ohba S, Yano F, Kawaguchi H, Chung U, Saito T, Yonehara Y, Nakatsuka T, Mori Y, Takato T, Hoshi K. Nanog promotes osteogenic differentiation of the mouse mesenchymal cell line　C3H10T1/2 by modulating bone morphogenetic protein (BMP) signaling. J Cell Physiol 228:163-171, 2013.
  • Yano F, Ikeda T, Saito T, Ogata N, Chikuda H, Hojo H, Kimura A, Takeda S, Nakamura K, Takato T, Kawaguchi H, Chung U. A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis 72:748-53、2013.
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2012

Ohba *: corresponding author

  • Hojo H, Ohba S*, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Takato T, Kawaguchi H, Chung UI: Gli1 protein participates in the hedgehog-mediated specification of the osteoblast lineage during endochondral ossification. J Biol Chem 287(21):17860-69, 2012.
  • Yamamoto K, Hojo H, Koshima I, Chung UI, Ohba S*: Famotidine suppresses osteogenic differentiation of tendon cells in vitro and pathological calcification of tendon in vivo. J Orthop Res 30(12):1958-1962, 2012.
  • Ohba S*, Hojo H, Chung UI: Bioactive factors for tissue regeneration: State of Art. Muscles, Ligaments and Tendons Journal (MTLJ) 2(3):193-203, 2012.
  • Ohba S, Hojo H, Chung UI: Current progress on tissue engineering of bone and cartilage. Endocrinol Metab 27(1):1-11, 2012.
  • Ogasawara T, Ohba S, Yano F, Kawaguchi H, Chung UI, Saito T, Yonehara Y, Nakatsuka T, Mori Y, Takato T, Hoshi K: Nanog promotes osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2 by modulating bone morphogenetic protein (BMP) signaling. J Cell Physiol (in press)
  • Yamamoto K, Hojo H, Koshima I, Chung UI, Ohba S*: Famotidine suppresses osteogenic differentiation of tendon cells in vitro and pathological calcification of tendon in vivo. J Orthop Res (in press)
  • Hojo H, Ohba S*, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Takato T, Kawaguchi H, Chung UI. Gli1 participates in the hedgehog-mediated specification of the osteoblast lineage during endochondral ossification. J Biol Chem (in press)
  • Ohba S, Hojo H, Chung UI. Current progress on tissue engineering of bone and cartilage. Endocrinol Metab 27(1), 1-11, 2012.

Tei/Chung 　

  • Nishi K, Chijiishi M, Katsumoto Y, Nakao T, Fujii K, Chung U, Noguchi H, Sakai T, Shibayama M. Rubber Elasticity for Incomplete Polymer Networks. J Chem Phys 137:224903, 2012.
  • Itoh S, Saito T, Hirata M, Ushita M, Ikeda T, Woodgett JR, Algl H, Schmid RM, Chung UI, and Kawaguchi H: GSK-3α and GSK-3β are involved in early stages of chondrocyte differentiation with functional redundancy through RelA phosphorylation. J Biol Chem 287:29227-36, 2012.
  • Lin L, Kayasuga Y, Shimohata N, Kamata H, Suzuki S, Echigo R, Mochizuki M, Chung U, Sasaki N. Lyophilized Aspirin with Trehalose May Decrease the Incidence of Gastric Injuries in Healthy Dogs. J Vet Med Sci 74:1511-6, 2012.
  • Kamata H, Chung U, Shibayama M, Sakai T. Anomalous volume phase transition in a polymer gel with alternative hydrophilic/amphiphilic sequence. Soft Matter 8:6876-6879, 2012.
  • Katashima T, Urayama K, Chung U, Sakai T. Strain energy density function of near-ideal polymer network estimated by biaxial deformation of Tetra-PEG gel. Soft Matter 8:8217-8222, 2012.
  • Yamamoto K, Hojo H, Koshima I, Chung U, Ohba S. Famotidine suppresses osteogenic differentiation of tendon cells in vitro and pathological calcification of tendon in vivo. J Orthop Res 30:1958-1962, 2012.
  • Echigo R, Shimohata N, Karatsu K, Yano F, Kayasuga-Kariya Y, Fujisawa A, Ohto T, Kita Y, Nakamura M, Suzuki S, Mochizuki M, Shimizu T, Chung U, Sasaki N. Trehalose treatment suppresses inflammation, oxidative stress, and vasospasm induced by experimental subarachnoid hemorrhage. J Tra Med 10:80,2012.
  • Hojo H, Ohba S, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Suzuki K, Takato T, Kawaguchi H, Chung U. Gli1 participates in the hedgehog-mediated specification of the osteoblast lineage during endochondral ossification. J Biol Chem 287:17860-17869, 2012.
  • Asai H, Fujii K, Ueki T, Sakai T, Chung U, Watanabe M, Han Y, Kim T, Shibayama M. Structural Analysis of High Performance Ion-gel Comprising Tetra-PEG Network. Macromolecules 45:3902-3909, 2012.
  • Choi S, Liu I, Yamamoto K, Igawa K, Mochizuki M, Sakai T, Ryosuke E, Honnami M, Suzuki S, Chung U, Sasaki N. Development and evaluation of tetrapod-shaped granular artificial bones. Acta Biomaterialia 8:2340-2347,2012.
  • Sakai T, Kurakazu M, Akagi Y, Shibayama M, Chung U. Effect of swelling and deswelling on the elasticity of polymer networks in dilute to semi-dilute region. Soft Matter 8:2730-2736, 2012.
  • Ha B,Nagaoka M, Yonezawa T, Tanabe R, Woo J, Kato H, Chung U, Yagasaki K. Regulatory mechanism for the stimulatory action of genistein on glucose uptake in vitro and in vivo. J Nutri Biochem 23:501-509, 2012.
  • Nishi K, Fujii K, Chijiishi M, Katsumoto Y, Chung U, Sakai T, Shibayama M. Kinetic Study for AB-type Coupling Reaction of Tetra-arm Polymers. Macromolecules 45:1031-1036,2012.
  • Fujii K, Asai H, Ueki T, Sakai S, Imaizumi S, Chung U, Watanabe M,Shibayama M. High-performance ion gel with Tetra-PEG network. Soft Matter 8:1756-1759,2012.
  • Hirata M, Kugimiya F, Fukai A, Saito T, Yano F, Ikeda T, Mabuchi A, Sapkota B, Akune T, Nishida N, Yoshimura N, Nakagawa T, Tokunaga K, Nakamura K, Chung U, Kawaguchi H. C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes. Hum Mol Genet 21:1111-1123,2012.
  • Lange F, Schwenke K, Kurakazu M, Akagi Y, Chung U, Lang M, Sommer J, Sakai T, Saalwaechter K. Connectivity and Structural Defects in Tetra-PEG Hydrogels: A Combined Proton NMR and Monte-Carlo Simulation Study Macromolecules 44:9666-9674,2012.
  • Ito S, Shimohata N, Iwanaga S, Ito W, Ohba M, Mochizuki M, Nakagawa T, Suzuki S, Sasaki N, Koshima I, Chung U. Prevention of intubation-induced mucosal damage using a protective coating with 2-metharcyloyloxyethyl phosphorylcholine polymer. Eur J Aneasthesiol 29:100-104,2012.
  • Fukai A, Kamekura S, Chikazu D, Nakagawa T, Hirata M, Saito T, Hosaka Y, Ikeda T, Nakamura K, Chung U, Kawaguchi H. Lack of chondroprotective effect of cyclooxygenase-2 inhibition in a mouse surgical osteoarthritis model. Arthritis Rheum 64:198-203,2012.
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2011

Ohba

    Tei/Chung 　

    • Choi S, Lee J, Igawa K, Suzuki S, Mochizuki M, Nishimura R, Chung U, Sasaki N. Effect of trehalose coating on basic fibroblast growth factor release from tailor-made artificial bone implant. J Vet Med Sci 73:1547-1552, 2011.
    • Akagi Y, Katashima T, Katsumoto Y, Fujii K, Matsunaga T, Chung U, Shibayama M, Sakai T. Examination of the theories of rubber elasticity using an ideal polymer network. Macromolecules 44:5817-5821, 2011.
    • Yonezawa T, Lee J, Hibino A, Asai M, Hojo H, Ha B,Teruya T, Nagai K, Chung U Yagasaki K, Woo J. Harmine promotes osteoblast differentiation through bone morphogenetic protein signaling. Biochem Biophys Res Commun 409:260-265, 2011.
    • Ogata N, Shinoda Y, Wettschureck N, Offermanns S, Takeda S, Nakamura K, Segre GV, Chung UI, Kawaguchi H. G{alpha}q Signal in Osteoblasts Is Inhibitory to the Osteoanabolic Action of Parathyroid Hormone. J Biol Chem 286:13733-40, 2011.
    • Li X, Tsutsui Y, Matsunaga T, Shibayama M, Chung U, Sakai T. Precise control and prediction of hydrogel degradation behavior. Macromolecules 44:3567-3571, 2011.
    • Fujino H, Lee S, Suzuki S, Chung U, Mochizuki M, Nishimura R, Sasaki N. Trehalose May Prevent Postsurgical Adhesions in a Rabbit Model of Hysterotomy. J Vet Med Sci 73:931-935, 2011.
    • Matsunaga T, Asai H, Akagi Y, Sakai T, Chung U, Shibayama M. SANS Studies on Tetra-PEG Gel under Uniaxial Deformation. Macromolecules 44:1203-1210,2011.
    • 26. Saijo H, Kanno Y, Mori Y, Suzuki S, Ohkubo K, Chikazu D, Yonehara Y, Chung U, Takato T. A novel method for designing and fabricating custom-made artificial bones. Int J Oral Maxillofac Surg 40:955-960, 2011.
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    2010

    Ohba

    • Hojo H, Ohba S,Yano F, Chung UI.
      Coordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development. J Bone Miner Metab (in press)
    • Hojo　H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Kan A, Ikeda T, Yonezawa T, Woo JT, Takato T, Nakamura K, Kawaguchi H, Chung UI.
      Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system. J Bone Miner Metab (in press)
    • Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, Kawaguchi H.
      Transcriptional regulation of endochondral ossification by HIF2A during skeletal growth and osteoarthritis development. Nat Med 16: 678-686, 2010.
    • Nakajima K, Komiyama Y, Hojo H, Ohba S, Yano F, Nishikawa N, Ihara S, Aburatani H, Takato T, Chung UI.
      Enhancement of bone formation ex vivo and in vivo by a helioxanthin-derivative. Biochem Biophys Res Commun 395: 502-508, 2010.
    • Zhao J, Ohba S, Komiyama Y, Shinkai M, Chung UI, Nagamune T.
      Icariin: A Potential Osteoinductive Compound for Bone Tissue Engineering. Tissue Eng Part A 16: 233-243, 2010.

    Tei/Chung 　

    • Hashimoto Y, Takasu M, Kawamoto S, Oda T, Nagao H, Sakai T, Chung U. Structure and dymanics of tetra-PEG gel by Brownian dynamics. Trans Mater Res Soc Japan 35:547-553, 2010.
    • Saijo H, Kanno Y, Mori Y, Suzuki S, Ohkubo K, Chikazu D, Yonehara Y, Chung U, Takato T. A novel method for designing and fabricating custom-made artificial bones. Int J Oral Maxillofac Surg (in press).
    • Sakai T, Matsunaga T, Akagi Y, Kurakazu M, Chung U, Shibayama M. Highly elastic and deformable hydrogel formed from tetra-arm polymers. Macromolecular Rapid Commun 31:1954-1959, 2010.
    • Hojo H, Ohba S, Yano F, Chung U. Coordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development. J Bone Miner Metab　28:489-502, 2010.
    • Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, and Kawaguchi H. Transcriptional regulation of endochondral ossification by HIF2A during skeletal growth and osteoarthritis development. Nature Med　16:678-683, 2010.
    • Fukasawa M, Sakai T, Chung U, Haraguchi K. Synthesis and mechanical properties of a nanocomposite gel consisting of a tetra-PEG/clay network. Macromolecules 43:4370-4378, 2010.
    • Mori Y, Yano F, Shimohata S, Suzuki S, Chung U, Takato T. Trehalose inhibits oral xerosis by protecting cell membrane. Int J Oral Maxillofac Surg 36:916-921, 2010.
    • Fröhlich LF, Mrakovcic M, Steinborn S, Chung U, Bastepe M, Jüppner H. Targeted deletion of the Nesp55 DMR provides evidence for another principal imprinting control region within Gnas and a mouse model of autosomal dominant pseudohypoparathyroidism type Ib. Proc Natl Acad Sci USA 107:9275-9280, 2010.
    • Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Ikeda T, Yonezawa T, Woo J, TakatoT, Nakamura K, Kawaguchi H, Chung U. Oxytetracycline induces chondrogenic differentiation without promoting terminal differentiation. J Bone Miner Metab 28:489-502, 2010.
    • Kurakazu M, Katashima T, Chijiishi M, Nishi K, Akagi Y, Matsunaga T, Shibayama M, Chung U, Sakai T. Evaluation of gelation kinetics of Tetra-PEG gel. Macromolecules 43:3935-3940, 2010.
    • Kimura A, Inose H, Yano F, Fujita F, Ikeda T, Sato S, Iwasaki M, Jinno T, Ae K, Fukumoto S, Takeuchi Y, Itoh H, Imamura T, Kawaguchi H, Chung U, Martin JF, Iseki S, Shinomiya K, Takeda S. Runx1 and Runx2 cooperate during sternum morphogenesis. Development 137:1159-1167, 2010.
    • Akagi Y, Matsunaga T, Shibayama M, Chung U, Sakai T. Evaluation of topological defects in Tetra-PEG gels. Macromolecules 43:488-493, 2010.
    • Wada M, Watanabe S, Chung U, Higo N, Taniguchi T, Kitazawa S. Noninvasive bioluminescence imaging of c-fos expression in the mouse barrel cortex. Behavioural Brain Research 208:158-162, 2010.
    • Fukai A, Kawamura N, Saito T, Oshima Y, Ikeda T, Kugimiya F, Higashikawa H, Yano F, Ogata N, Nakamura K, Chung U, Kawaguchi H. Akt1 in chondrocytes controls cartilage calcification during endochondral ossification under physiological and pathological conditions. Arthritis Rheum 62:826-836, 2010.
    • Shinoda Y, Kawaguchi H, Higashikawa A, Nakamura K, Chung U, and Ogata N. Mechanisms underlying catabolic and anabolic functions of parathyroid hormone on bone by combination of culture systems of mouse cells. J Cell Biochem 109:755-763, 2010.
    • Zhao J, Ohba S, Komiyama Y, Shinkai M, Chung U, Nagamune T. Icariin: A potential osteoconductive compound for bone tissue engineering. Tissue Eng Part A 16:233-243, 2010.
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    2009

    Ohba 　

    • Ohba S, Yano F, Chung UI.
      Tissue engineering of bone and cartilage. IBMS BoneKEy 6: 405-419, 2009.
    • Ogasawara T, Ohba S, Fujihara Y, Takahashi T, Liu G, Chikazu D, Suenaga H, Chung UI, Yoda T, Mori Y, Susami T, Takato T, Hoshi K.
      Transforming growth factor-b1 in combination with fibroblast growth factor-2 and insulin-like growth factor-I for chondrocyte proliferation culture and cartilage regenerative medicine. Asian J Oral Maxillofac Surg 21: 18-26, 2009.
    • Wang W, Itaka K, Ohba S, Nishiyama N, Chung UI, Yamasaki Y, Kataoka K.
      3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells. Biomaterials 30: 2705-2715, 2009.
    • Zhao J, Shinkai M, Takezawa T, Ohba S, Chung UI, Nagamune T.
      Bone regeneration using collagen type I vitrigel with bone morphogenetic protein-2. J Biosci Bioeng 107: 318-323, 2009.
    • Hirata M, Kugimiya F, Fukai A, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Saito T, Yano F, Ikeda T, Nakamura K, Chung UI, Kawaguchi H.
      C/EBPβ promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57Kip2. PLoS ONE 4(2), e4543, 2009.

    Tei/Chung 　

    • Lee S, Miwa Y, Nishimura R, Chung U, Suzuki S, Sasaki N. Effects of trehalose and sodium carboxymethyl cellulose on prevention of organ adhesion after laparotomy: a preclinical study. Jpn J Vet Aneth Surg 40:19-26, 2009.
    • Choi SJ, Lee JI, Igawa K, Sugimori O, Suzuki S, Mochizuki M, Nishimura R, Chung UI, Sasaki N. Bone regeneration within a tailor-made tricalcium phosphate bone implant with both horizontal and vertical cylindrical holes transplanted into the skull of dogs. J Artif Organs 12:274-7, 2009.
    • Ohba S, Yano F, Chung U. Tissue engineering of bone and cartilage. IBMS Bone KEy 6:405-419, 2009.
    • Matsunaga T, Sakai T, Akagi Y, Chung U, Shibayama M. SANS and SLS Studies on Tetra-Arm PEG Gels in As-prepared and Swollen States. Macromolecules 42:6245-6252, 2009.
    • Saijo H, Kanno Y, Igawa K, Mori Y, Kondo K, Shimizu K, Suzuki S, Chikazu D, Iino M, Sasaki N, Anzai M, Chung U, Takato T. Maxillofacial reconstruction using custom-made artificial bones fabricated by inkjet printing technology. J Artif Organs 12:200-205, 2009.
    • Chung U. Manufacturing of artificial bones using 3D inkjet printing technology. Int J Automation Technology 3:509-513, 2009.
    • Matsunaga T, Sakai T(Co-first), Akagi Y, Chung U, Shibayama M. Structure characterization of Tetra-PEG Gel by Small-angle Neutron Scattering. Macromolecules 42:1344-51, 2009.
    • Adams GB, Alley IR, Chung U, Chabner KT, Marsters ES, Chen M, Weinstein LS, Kronenberg HM, Scadden DT. Haematopoietic stem cells depend on Gαs-mediated signalling to engraft bone marrow. Nature 459:103-7, 2009.
    • Kan A, Ikeda T, Saito T, Yano F, Ogata N, Nakamura K, Chung U, Kawaguchi H. Screening of Chondrogenic Factors by a Real-Time Fluorescence Monitoring Cell Line ATDC5-C2ER: Identification of Sorting Nexin 19 as a Novel Factor. Arthritis Rheum 60:3314-3323, 2009.
    • Ogasawara T, Ohba S, Fujihara Y, Takahashi T, Liu G, Chikazu D, Suenaga H, Chung U, Yoda T, Mori Y, Susami T, Takato T, Hoshi K. Effects of transforming growth factor (TGF)-β1 in combination with fibroblast growth factor (FGF)-2 and insulin-like growth factor (IGF)-I on chondrocytes proliferation culture for the cartilage regenerative medicine. Asian J Oral Maxillofac Surg (in press)
    • Liu G, Ogasawara T, Watanabe J, Ishihara K, Asawa K, Chung U, Moro T, Takatori T, Takato T, Nakamura K, Kawaguchi H, Hoshi K. Selection of highly osteogenic and chondrogenic cells from bone marrow　stromal cells in biocompatible polymer-coated plates. J Biomed Mater Res A 92A:1273-1282, 2009.
    • Ushita M, Saito T, Ikeda T, Yano F, Higashikawa A, Ogata N, Chung UI, Nakamura K, Kawaguchi H. Transcriptional induction of SOX9 by NF-κB family member RelA in chondrogenic cells. Osteoarthritis Cartilage 17:1065-1075, 2009.
    • Wang W, Itaka K, Ohba S, Nishiyama N, Chung U, Yamasaki Y, Kataoka K. 3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells. Biomaterials 30:2705-15, 2009.
    • Yamamoto K, Igawa K, Ueno H, Yano F, Chung U, Koshima I. Temporal and spatial changes in element distribution in bone and cartilage. J Orthop Sci 14:190-203, 2009.
    • Zhao J, Shinkai M, Takezawa T, Ohba S, Chung U, Nagamune T. Bone Regeneration Using Collagen Type I Vitrigel with Bone Morphogenetic Protein-2. J Biosci Bioeng 107:318-323, 2009.
    • Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Nakamura K, Chung U, Kawaguchi H. Identification of the core element responsive to Runx2 in the promoter of human type X collagen gene. Arthritis Rheum 60:166-178, 2009.
    • Hirata M, Kugimiya F, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Fukai A, Ikeda T, Nakamura K, Chung UI, Kawaguchi H. C/EBPβ promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57Kip2. PLoS ONE 4:e4543, 2009.
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    2008

    Ohba

    • Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Nakamura K, Chung UI, Kawaguchi H.
      Identification of the core element responsive to Runx2 in the promoter of human type X collagen gene. Arthritis Rheum 60: 166-178, 2008.
    • Hojo H, Igawa K, Ohba S, Yano F, Nakajima K, Komiyama Y, Ikeda T, Lichtler AC, Woo JT, Yonezawa T, Takato T, Chung UI.
      Development of high-throughput screening system for osteogenic drugs using a cell-based sensor. Biochem Biophys Res Commun 376: 375-379, 2008.
    • Ohba S, Kawaguchi H, Kugimiya F, Ogasawara T, Kawamura N, Saito T, Ikeda T, Fujii K, Miyajima T, Kuramochi A, Miyashita T, Oda H, Nakamura K, Takato T, Chung UI.
      Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity. Dev Cell 14: 689-699, 2008.
    • Tamiya H, Ikeda T, Jung JH, Saito T, Jung YK, Ohba S, Kawaguchi H, Chung UI, Choi JY.
      Analysis of the Runx2 promoter in osseous and non-osseous cells and identification of HIF2A as a potent transcriptional activator. Gene 416: 53-60, 2008.
    • Zhao J, Ohba S, Shinkai M, Chung UI, Nagamune T.
      Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner. Biochem Biophys Res Commun 369: 444-448, 2008.

    Tei/Chung 　

    • Sakai T, Matsunaga T, Yamamoto Y, Ito C, Yoshida R, Sasaki N, Suzuki S, Shibayama M, Chung U. Design and fabrication of a high-strength hydrogel with ideally homogeneous network structure from tetrahedron-like macromonomers. Macromolecules 41:5379-84, 2008.
    • Saijo H, Chung U, Igawa K, Mori Y, Chikazu D, Iino M, Takato T. Clinical application of artificial bone in the maxillofacial region. J Artif Organs 11:171-6, 2008.
    • Hojo H, Igawa K, Ohba S, Yano F, Nakajima K, Komiyama Y, Ikeda T, Lichtler AC, Woo J-T, Yonezawa T, Takato T, Chung U. Development of high-throughput screening system for osteogenic drugs using a cell-based sensor. Biochem Biophys Res Commun 376:375-379, 2008.
    • Lee S, Hong SW, Choi HS, Lee LY, Nam C, Rhee Y, Chung UI, Lim SK. Experimental Parathyroid Hormone Gene Therapy using ØC31 Integrase. Endocr J 55:1033-1041, 2008.
    • Oshima Y, Akiyama T, Hikita A, Iwasawa M, Nagase Y, Nakamura M, Wakeyama H, Kawamura N, Ikeda T, Chung U, Hennighausen L, Kawaguchi H, Nakamura K, Tanaka S. Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis. J Biol Chem 283:26499-508, 2008.
    • Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, and Kawaguchi H: Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9. J Biol Chem 283:24682-9, 2008.
    • Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, Ogata N, Hoshi K, Hofmann F, Woodgett JR, Nakamura K, Chung U, Kawaguchi H. Phosphorylation of GSK-3β by cyclic GMP-dependent protein kinase II promotes chondrocyte hypertrophy and skeletal growth. J Clin Invest 118: 2506-2515, 2008.
    • Wu S, Nishiyama N, Kano MR, Morishita Y, Miyazono K, Itaka K, Chung UI, Kataoka K. Enhancement of Angiogenesis Through Stabilization of Hypoxia-inducible Factor-1 by Silencing Prolyl Hydroxylase Domain-2 Gene. Mol Ther 16:1227-34, 2008.
    • Ohba S, Kawaguchi H, Kugimiya F, Ogasawara T, Kawamura N, Saito T, Ikeda T, Fujii K, Miyajima T, Kuramochi A, Miyashita T, Oda H, Nakamura K, Takato T, Chung U. Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity. Dev Cell 14:689-699, 2008.
    • Tamiya H, Ikeda T, Jung JH, Saito T, Jung YK, Kawaguchi H, Ohba S, Chung UI, and Choi JY: Analysis of the Runx2 promoter in osseous and non-osseous cells and identification of HIF2A as a potent transcriptional activator. Gene 416:53-60, 2008.
    • Yamakawa K, Kamekura S, Kawamura N, Saegusa M, Kamei D, Murakami M, Kudo I, Uematsu S, Akira S, Chung U, Nakamura K, Kawaguchi H. Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders. Arthritis Rheum 58:172-183, 2008.
    • Zhao J, Shinkai M, Ohba S, Chung U, Nagamune T. Icariin induce osteoblastic differentiation in vitro by a BMP and runx2 pathway. Biochem Biophys Res Commun 369:444-448, 2008.
    • Jang K, Sato K, Igawa K, Chung U, Kitamori T.　Development of an osteoblast cell-based 3D continuous perfusion microfluidic system for drug screening. Analytical Bioanalytical Chemistry 390:825-832, 2008.
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    2007

    Ohba 　

    • Kawamura N, Kugimiya F, Oshima Y, Ohba S, Ikeda T, Saito T, Shinoda Y, Kawasaki Y, Ogata N, Hoshi K, Akiyama T, Tobe T, Kadowaki T, Azuma Y, Tanaka S, Nakamura K, Chung UI, Kawaguchi H.
      Akt1 in osteoblasts and osteoclasts controls bone remodeling. PLoS ONE 2: e1058, 2007.
    • Kugimiya F, Kawaguchi H, Ohba S, Kawamura N, Hirata M, Chikuda H, Azuma Y, Woodgett J, Nakamura K, Chung UI.
      GSK-3β controls osteogenesis through regulating Runx2 activity. PLoS ONE 2: e837, 2007.
    • Itaka K, Ohba S (co-first), Miyata K, Kawaguchi H, Nakamura K, Takato T, Chung UI, Kataoka K.
      Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles. Mol Ther 15: 1655-1662, 2007.
    • Ohba S, Ikeda T, Kugimiya F, Yano F, Lichtler AC, Nakamura K, Takato T, Kawaguchi H, Chung UI.
      Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell-based sensor. FASEB J 21: 1777-1787, 2007.
    • Ohba S, Nakajima K, Komiyama Y, Kugimiya F, Igawa K, Itaka K, Moro T, Nakamura K, Kawaguchi H, Takato T, Chung UI.
      A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner. Biochem Biophys Res Commun 357: 854-860, 2007.

    Tei/Chung 　

    • Chung U, Itaka K, Nishiyama N, Takato T, Kawaguchi H, Nakamura K, Kataoka K. Scaffolds for skeletal regeneration. NanoBioTechnology 3:104-106, 2007.
    • Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung UI, Xavier R, Alt FW, Snapper SB.　Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development. Proc Natl Acad Sci U S A 104:15424-15429, 2007.
    • Ogata N, Kawaguchi H, Chung U, Roth SI, and Segre GV. Continuous activation of Gαq in osteoblasts results in osteopenia through impaired osteoblast differentiation. J Biol Chem 282:35757-35764, 2007.
    • Kawamura N, Kugimiya F, Oshima Y, Ohba S, Ikeda T, Saito T, Shinoda Y, Kawasaki Y, Ogata N, Hoshi K, Akiyama T, Tobe T, Kadowaki T, Azuma Y, Tanaka S, Nakamura K, Chung UI, and Kawaguchi H. Akt1 in osteoblasts and osteoclasts controls bone remodeling. PLoS ONE 2:e1058, 2007.
    • Kugimiya F, Kawaguchi H, Ohba S, Kawamura N, Chikuda H, Azuma Y, Woodgett J, Nakamura K, Chung U. GSK-3β controls osteogenesis through regulating Runx2 activity. PLoS ONE 2:e837, 2007.
    • Masago K, Itaka K, Nishiyama N, Chung U, Kataoka K. Gene delivery with biocompatible cationic polymer: Pharmacogenomic analysis on cell bioactivity. Biomaterials 28:5169-5175, 2007.
    • Shimizu S, Asou Y, Itoh S, Chung UI, Kawaguchi H, Shinomiya K, Muneta T. Prevention of cartilage destruction with intraarticular osteoclastogenesis inhibitory factor/osteoprotegerin in a murine model of osteoarthritis. Arthritis Rheum 56: 3358-3365, 2007.
    • Itaka K, Ohba S, Chung U, Kataoka K. Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles. Mol Ther 15: 1655-1662, 2007.
    • Liu G, Kawaguchi H, Ogasawara T, Asawa Y, Kishimoto JI, Takahashi T, Chung U, Yamaoka H, Asato H, Nakamura K, Takato T, Hoshi K. Optimal combination of soluble factors for tissue engineering of permanent cartilage from cultured human chondrocytes. J Biol Chem 282: 20407-20415, 2007.
    • Ohba S, Nakajima K, Kugimiya F, Igawa K, Itaka K, Moro T, Nakamura K , Kawaguchi H, Takato T, Chung U. A novel compound, TH, induces osteogenic differentiation in a BMP-dependent manner. Biochem Biophys Res Commun 357: 854-860, 2007.
    • Ikeda T, Saito T, Ushita M, Yano F, Kan A, Itaka K, Moro T, Nakamura K, Kawaguchi H, Chung U. Identification and characterization of the human SOX6 promoter. Biochem Biophys Res Commun 357:383-390, 2007.
    • Saito T, Ikeda T, Nakamura K, Chung UI, Kawaguchi H. S100A1 and B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes. EMBO Rep 8:504-509, 2007.
    • Ohba S, Ikeda T, Kugimiya F, Yano F, Lichtler AC, Nakamura K, Takato T, Kawaguchi H, Chung U. Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell-based sensor. FASEB J 21:1777-1787, 2007.
    • Kosaki N, Kamekura S, Kimura T, Okada Y, Minqi L, Amizuka N, Chung U, Nakamura K, Kawaguchi H, Toyama Y, D'Armiento J, Takaishi H. Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice. Biochem Biophys Res Commun 354:846-851, 2007.
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    2006

    Ohba 　

    • Kugimiya F, Ohba S, Nakamura K, Kawaguchi H, Chung UI.
      Physiological role of bone morphogenetic proteins in osteogenesis. J Bone Miner Metab 24:, 95-99, 2006.

    Tei/Chung 　

    • Igawa K, Mochizuki M, Sugimori O, Shimizu K, Yamazawa K, Kawaguchi H, Nakamura K, Takato T, Nishimura R, Suzuki S, Anzai M, Chung U, Sasaki N.
      Tailor-made tricalcium phosphate bone implant directly fabricated by a three-dimensional ink-jet printer. J Artif Organ 9: 234-240, 2006.
    • Bounoutas GS, Tawfeek H, Fröhlich LF, Chung U, Abou-Samra AB.
      Impact of impaired receptor internalization on calcium homeostasis in knock-in mice expressing a phosphorylation-deficient parathyroid hormone (PTH)/PTH-related peptide receptor. Endocrinology 147: 4674-4679, 2006.
    • Provot S, Kempf H, Murtaugh C, Chung U, Kim DW, Chyung J, Kronenberg HM, Lassar AB.
      Nkx3.2/Bapx1 acts as a negative regulator of chondrocyte maturation. Development 133: 651-662, 2006.
    • Kanayama N, Fukushima S, Nishiyama N, Itaka K, Jang W, Miyata K, Yamasaki Y, Chung U, Kataoka K.
      A PEG-Based Biocompatible Block Catiomer with High Buffering Capacity for the Construction of Polyplex Micelles Showing Efficient Gene Transfer toward Primary Cells. ChemMedChem 1: 439-444, 2006.
    • Guo J, Chung U, Yang D, Karsenty G, Bringhurst R, Kronenberg HM.
      PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways. Dev Biol 292: 116-128, 2006.
    • Yamada T, Kawano H, Koshizuka Y, Fukuda T, Yoshimura K, Kamekura S, Saito T, Ikeda T, Kawasaki Y, Azuma Y, Ikegawa S, Hoshi K, Chung U, Nakamura K, Kato S, Kawaguchi H.
      Carminerin contributes to chondrocyte calcification　during endochondral ossification. Nat Med 12: 665-670, 2006.
    • Kugimiya F, Ohba S, Nakamura K, Kawaguchi H, Chung U.
      Physiological role of bone morphogenetic proteins in osteogenesis. J Bone Miner Metab 24: 95-99, 2006.
    • Shinoda Y, Yamaguchi M, Ogata N, Akune T, Kubota N, Yamauchi T, Terauchi Y, Kadowaki T, Takeuchi Y, Fukumoto S, Ikeda T, Hoshi K, Chung U, Nakamura K, Kawaguchi H.
      Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. J Cell Biochem 99: 196-208, 2006.
    • Katagiri M, Ogasawara T, Hoshi K, Chikazu D, Kimoto A, Noguchi M, Sasamata M, Harada S, Akama H, Tazaki H, Chung U, Takato T, Nakamura K, Kawaguchi H.
      Suppression of adjuvant-induced arthritic bone destruction by cyclooxygenase-2 selective agents with and without inhibitory potency against carbonic anhydrase II. J Bone Miner Res 21: 219-227, 2006.
    • Yamaoka H, Asato H, Ogasawara T, Nishizawa S, Takahashi T, Nakatsuka T, Koshima I, Nakamura K, Kawaguchi H, Chung U, Takato T, Hoshi K.
      Cartilage tissue engineering using human auricular chondrocytes embedded in different hydrogel materials. J Biomed Mater Res A 78: 1-11, 2006.
    • Kamekura S, Kawasaki Y, Hoshi K, Shimoaka T, Chikuda H, Maruyama Z, Komori T, Sato S, Takeda S, Karsenty G, Nakamura K, Chung U, Kawaguchi H:
      Contribution of runt-related transcription factor 2 to pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum 54: 2462-2470, 2006.
    • Zhao B, Katagiri T, Toyoda H, Takada T, Yanai T, Fukuda T, Chung U, Koike T, Takaoka K, Kamijo R.
      Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-2. J Biol Chem 281: 23246-23253, 2006.
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    2005

    Ohba 　

    • Kugimiya F, Yano F, Ohba S, Igawa K, Nakamura K, Kawaguchi H, Chung UI.
      Mechanism of osteogenic induction by FK506 via BMP/Smad pathways. Biochem Biophys Res Commun 338: 872-879, 2005.
    • Kugimiya F, Kawaguchi H, Kamekura S, Chikuda H, Ohba S, Yano F, Ogata N, Katagiri T, Harada Y, Azuma Y, Nakamura K, Chung UI.
      Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation. J Biol Chem 280: 35704-35712, 2005.
    • Kawaguchi H, Akune T, Yamaguchi M, Ohba S, Ogata N, Chung UI, Kubota N, Terauchi Y, Kadowaki T, Nakamura K.
      Distinct effects of PPARgamma insufficiency on bone marrow cells, osteoblasts, and osteoclastic cells. J Bone Miner Metab 23: 275-279, 2005.
    • Yano F, Kugimiya F, Ohba S, Ikeda T, Chikuda H, Ogasawara T, Ogata N, Takato T, Nakamura K, Kawaguchi H, Chung UI.
      The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner. Biochem Biophys Res Commun 333: 1300-1308, 2005.
    • Chikazu D, Ohba S, Ogasawara T, Saijyo H, Mori Y, Tomizuka K, Kawaguchi H, Yonehara Y, Susami T, Takato T.
      Combination of platelet-rich plasma and cyclooxygenase-2 inhibitor potently stimulates bone marrow stromal cell proliferation in vitro. Asian J Oral Maxillofac Surg 17: 81-87, 2005.

    Tei/Chung 　

    • Yano F, Kugimiya F, Ohba S, Ikeda T, Chikuda H, Ogasawara T, Ogata N, Takato T, Nakamura K, Kawaguchi H, Chung U.
      The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner. Biochem Biophys Res Commun 333: 1300-1308, 2005.
    • Kugimiya F, Kawaguchi H, Kamekura S, Chikuda H, Ohba S, Yano F, Ogata N, Katagiri T, Harada Y, Azuma Y, Nakamura K, Chung U.
      Involvement of endogenous bone morphogenetic protein (BMP)2 and BMP6 in bone formation. J Biol Chem 280: 35704-35712, 2005
    • Kugimiya F, Yano F, Ohba S, Igawa K, Nakamura K, Kawaguchi H, Chung U.
      Mechanism of osteogenic induction by FK506 via BMP/Smad pathways. Biochem Biophys Res Commun 338: 872-879, 2005.
    • Moro T, Ogasawara T, Chikuda H, Ikeda T, Ogata N, Maruyama Z, Komori T, HoshiK, Chung U, Nakamura K, Okayama H, Kawaguchi K.
      Inhibition of Cdk6 expression through p38 MAP kinase is involved in differentiation of mouse prechondrocyte ATDC5. J Cell Physiol 204: 927-933, 2005.
    • Yamaguchi M, Ogata N, Shinoda Y, Akune T, Kamekura S, Terauchi Y, Kadowaki T, Hoshi K, Chung U, Nakamura K, Kawaguchi H.
      Insulin receptor substrate-1 is required for bone anabolic function of parathyroid hormone in mice. Endocrinology 146: 2620-2628, 2005.
    • Chikuda H, Kugimiya F, Hoshi K, Ikeda T, Ogasawara T, Kamekura S, Ogata N, Nakamura K, Chung U, Kawaguchi H.
      Mutation in cGMP-dependent protein kinase II causes dwarfism in a rat mutant KMI through uncoupling of proliferation and differentiation of chondrocytes. J Bone Miner Metab 23: 200-204, 2005.
    • Kawaguchi H, Akune T, Yamaguchi M, Ohba S, Ogata N, Chung U, Kubota N, Terauchi Y, Kadowaki T, and Nakamura K.
      Distinct effects of PPARgamma insufficiency on bone marrow cells, osteoblasts, and osteoclastic cells. J Bone Miner Matab 23: 275-279, 2005.
    • Kamekura S, Hoshi K, Shimoaka T, Chung U, Chikuda H, Yamada T, Uchida M, Ogata N, Seichi A, Nakamura K, Kawaguchi H.
      Osteoarthritis development in novel experimental mouse models induced by knee joint instability. Osteoarthritis Cartilage 13: 632-641, 2005.
    • Ikeda T, Kawaguchi H, Kamekura S, Ogata N, Mori Y, Nakamura K, Ikegawa S, Chung U.
      Distinct roles of Sox5, Sox6, and Sox9 in different stages of chondrogenic differentiation. J Bone Miner Metab 23: 337-340, 2005.
    • Lee S, Hwang R, Lee J, Rhee Y, Kim DJ, Chung U, Lim S-K.
      Ectopic expression of vasopressin V1b and V2 receptors in the adrenal glands of familial ACTH-independent macronodular adrenal hyperplasia. Clin Endocrinol (Oxf) 63: 625-630, 2005.
    • Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Hoshi K, Ogasawara T, Nakamura K, Chung U, Kawaguchi H.
      Involvement of cyclic guanosine monophosphate-dependent protein kinase II in chondrocyte hypertrophy during endochondral ossification. Mod Rheumatol 15: 391-396, 2005.
    • Takahashi T, Ogasawara T, Kishimoto J, Liu G, Asato H, Nakatsuka T, Uchimura T, Nakamura K, Kawaguchi H, Chung U, Takato T, Hoshi K.
      Synergistic effects of FGF-2 with insulin or IGF-I on the proliferation of human auricular chondrocytes. Cell Transplant 14: 683-693, 2005.
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    2004

    Ohba 　

    • Akune T, Ohba S, Kamekura S, Yamaguchi M, Chung UI, Kubota N, Terauchi Y, Harada Y, Azuma Y, Nakamura K, Kadowaki T, Kawaguchi H.
      PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 113: 846-855, 2004.
    • Long F, Chung UI, Ohba S, McMahon J, Kronenberg HM, McMahon AP.
      Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131: 1309-1318, 2004.

    Tei/Chung 　

    • Bastepe M, Weinstein LS, Ogata N, Kawaguchi H, Jüppner H, Kronenberg HM, Chung U.
      Stimulatory G protein (Gs) directly regulates hypertrophic differentiation of growth plate cartilage in vivo. Proc Natl Acad Sci U S A 101: 14794-14799, 2004.
    • Ikeda T, Kamekura S, Mabuchi A, Kou I, Seki S, Takato T, Nakamura K, Kawaguchi H, Ikegawa S, Chung U.
      The combination of SOX5, SOX6 and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. Arthritis Rheum 50: 3561-3573, 2004.
    • Chikuda H, Kugimiya F, Hoshi k, Ikeda T, Ogasawara T, Shimoaka T, Kawano H, Kamekura S, Tsuchida A, Yokoi N, Nakamura K, Komeda K, Chung U, Kawaguchi H.
      Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes. Genes Dev 18: 2418-2429, 2004.
    • Chung U.
      Essential role of hypertrophic chondrocytes in endochondral bone development. Endocr J 51: 19-24, 2004.
    • Moro T, Takatori Y, Ishihara K, Konno T, Takigawa Y, Matsushita T, Chung U, Nakamura K, Kawaguchi H.
      Surface grafting of artificial joints with a biocompatible polymer for preventing periprosthetic osteolysis. Nat Mater 3: 829-836, 2004.
    • Hoshi K, Ogata N, Shimoaka T, Terauchi Y, Kadowaki T, Kenmotsu S, Chung U, Ozawa H, Nakamura K, Kawaguchi H.
      Deficiency of insulin receptor substrate-1 impairs skeletal growth through early closure of epiphyseal cartilage. J Bone Miner Res 19: 214-223, 2004.
    • Long F, Chung U (Co-first), Ohba S, McMahon J, Kronenberg HM, McMahon AP.
      Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131: 1309-1318, 2004.
    • Seto H, Kamekura S, Miura T, Yamamoto A, Chikuda H, Ogata T, Hiraoka H, Oda H, Nakamura K, Kurosawa H, Chung U, Kawaguchi H, Tanaka S.
      Distinct roles of Smad pathways and p38 pathways in cartilage-specific gene expression in synovial fibroblasts. J Clin Invest 113: 718-726, 2004.
    • Shimoaka T, Kamekura S, Chikuda H, Hoshi K, Chung U, Akune T, Maruyama Z, Komori T, Matsumoto M, Ogawa W, Terauchi Y, Kadowaki T, Nakamura K, Kawaguchi H.
      Impairment of bone healing by insulin receptor substrate-1 deficiency. J Biol Chem 279: 15314-15322, 2004.
    • Akune T, Ohba S, Kamekura S, Yamaguchi M, Chung U, Kubota N, Terauchi Y, Harada Y, Azuma Y, Nakamura K, Kadowaki T, Kawaguchi H.
      PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 113: 846-855, 2004.
    • Chung U, Kawaguchi H, Takato T, Nakamura K.
      Distinct osteogenic mechanisms of bones of distinct origins. J Orthop Sci 9: 410-414, 2004.
    • Yamada T, Kawano H, Sekine K, Matsumoto T, Fukuda T, Azuma Y, Itaka K, Chung U, Chambon P, Nakamura K, Kato S, Kawaguchi H.
      SRC-1 is necessary for skeletal responses to sex hormones in both males and females. J Bone Miner Res 19: 1452-1461, 2004.
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    2003

    Ohba 　

      Tei/Chung 　

      • Koshizuka Y, Yamada T, Hoshi K, Ogasawara T, Chung U, Kawano H, Nakamura Y, Nakamura K, Ikegawa S, Kawaguchi H.
        Cystatin 10, a novel chondrocyte-specific protein, may promote the last step of the chondrocyte differentiation pathway. J Biol Chem 278: 48259-48266, 2003.
      • Akiyama T, Bouillet P, Miyazaki T, Kadono Y, Chikuda H, Chung U, Fukuda A, Hikita A, Seto H, Okada T, Inaba T, Sanjay A, Baron R, Kawaguchi H, Oda H, Nakamura K, Strasser A, Tanaka S.
        Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO J 22: 6653-6664, 2003.
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      Before 2002

      Ohba 　

        Ohba S, Suzuki T, Ooya K.
        Immunohistochemical expression of integrins and CD44 in ameloblastoma. Oral Med Pathol 6: 73-78, 2001.

      Tei/Chung 　

      • Guo J, Chung U, Kondo H, Bringhurst FR, Kronenberg HM.
        The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C. Dev Cell 3: 183-194, 2002.
      • Kobayashi T, Chung U, Schipani E, Starbuck M, Karsenty G, Katagiri T, Goad DL, Lanske B, Kronenberg HM.
        PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps. Development 129: 2977-2986, 2002.
      • Kronenberg HM, Chung U.
        The parathyroid hormone-related protein and Indian hedgehog feedback loop in the growth plate. Novartis Found Symp 232: 144-157, 2001.
      • Huang W, Chung U, Kronenberg H, de Crombrugghe B.
        The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones. Proc Natl Acad Sci USA 98: 160-165, 2001.
      • Chung U, Schipani E, McMahon AP, Kronenberg H.
        Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J Clin Invest 107: 295-304, 2001.
      • Ramirez MI, Chung U, Williams MC.
        Aquaporin-5 expression, but not other peripheral lung marker genes, is reduced in PTH/PTHrP receptor null mutant fetal mice. Am J Respir Cell Mol Biol 22: 367-372, 2000.
      • Watson PH, Fraher LJ, Hendy GN, Chung U, Kisiel M, Natale BV, Hodsman AB.
        Nuclear localization of the type 1 PTH/PTHrP receptor in rat tissues. J Bone Miner Res 15: 1033-1034, 2000.
      • Chung U, Kronenberg HM.
        Parathyroid hormone-related peptide and Indian hedgehog. Curr Opin Nephrol Hypertens 9: 357-362, 2000.
      • Verheijen MH, Karperien M, Chung U, van Wijuen M, Heystek H, Hendricks JA, Veltmaat JM, Lanske B, Li E, Lowik CW, de Laat SW, Kronenberg HM, Defize LH.
        Parathyroid hormone-related peptide (PTHrP) induces parietal endoderm formation exclusively via the type I PTH/PTHrP receptor. Mech Dev 81: 151-161, 1999.
      • Kronenberg HM, Lanske B, Kovacs CS, Chung U, Lee K, Segre GV, Schipani E, Jüppner H.
        Functional analysis of the PTH/PTHrP network of ligands and receptors. Recent Prog Horm Res 53: 283-303, 1998.
      • Chung U, Lanske B, Lee K, Li E, Kronenberg H.
        The parathyroid hormone/parathyroid hormone-repated peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation. Proc Natl Acad Sci USA 95: l3030-l3035, 1998.
      • Hirakata M, Kaname S, Chung U, Joki N, Hori Y, Noda M, Takuwa Y, Okazaki T, Fujita T, Katoh T, Kurokawa K.
        Tyrosine kinase dependent expression of TGF-beta induced by stretch in mesangial cells. Kidney Int 51: 1028-1036, 1997.
      • Chung U, Igarashi T, Nishishita T, Iwanari H, Iwamatsu A, Suwa A, Mimori T, Hata K, Ebisu S, Ogata E, Fujita T, Okazaki T.
        The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium. J Biol Chem 271: 8593-8598, 1996.
      • Chung U, Tanaka Y, Fujita T.
        Association of interleukin-6 and hypoaldosteronism in patients with cancer. N Engl J Med 334: 473, 1996.
      • Okazaki T, Chung U, Nishishita T, Ebisu S, Usuda S, Mishiro S, Xanthoudakis S, Igarashi T, Ogata E.
        A redox factor protein, ref1, is involved in negative gene regulation by extracellular calcium. J Biol Chem 269: 27855-27862, 1994.
      • Chung U, Oka M, Nakagawa Y, Nishishita T, Sekine N, Tanaka Y, Harada S, Igarashi T, Ogata E.
        A patient with protein-losing enteropathy associated with systemic lupus erythematosus. Intern Med 31: 521-524, 1992.
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      Books

      Ohba 　

        Tei/Chung 　

        • Chung U, Kronenberg H.
          Role of parathyroid hormone-related protein and Indian hedgehog in skeletal development. In: Skeletal Growth Factors, ed. Ernesto Canalis (Lippincott, Williams & Wilkins), p.355-364, 2000.
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